Royal (Dick) School of Veterinary Studies thesis and dissertation collection: Recent submissions
Now showing items 1-20 of 759
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Role of budding morphology in pathogenesis and transmission of avian influenza A virus
(The University of Edinburgh, 2019-11-27)Pleomorphism is a characteristic of influenza A virus (IAV), which can produce spherical particles of ~100 nm in diameter and filaments up to 30 μm in length. Laboratory-adapted strains mainly produce spherical virions, ... -
CRISPR/Cas9-based strategies for pig host resistance to Influenza A virus
(The University of Edinburgh, 2019-11-27)Influenza circulates in different mammalian and avian species, causing epidemics and occasional pandemics. This poses a substantial threat to agricultural productions, animal welfare, human public health, and economy. ... -
Manipulating cell lines with CRISPR/Cas9 to investigate Foot and Mouth Disease Virus infection
(The University of Edinburgh, 2019-11-27)With the world population expected to reach 9.7 billion by 2050; food security is a growing concern. As animal protein is one of the most accessible proteins available to people in the developing world, reducing disease ... -
Specific diagnostic tools for protozoan infection of ruminants
(The University of Edinburgh, 2019-06-29)Neospora caninum, Toxoplasma gondii and Sarcocystis spp. are closely related intracellular protozoan parasites causing neosporosis, toxoplasmosis and sarcocystosis, respectively. Toxoplasma and Neospora are major causes ... -
Exploring spatial ability in veterinary students and the relationship to teaching methods
(The University of Edinburgh, 2019-06-29)Anatomy is the foundation to most medical disciplines, and a sound understanding is required to underpin many aspects ranging from routine physical examination to complex surgical procedures. For qualified veterinary ... -
Neuroendocrine control of maternal behaviour in birds
(The University of Edinburgh, 2019-06-29)Maternal behaviour in humans and animals promotes the survival and future success of offspring. It is mainly controlled by the brain behaviour network in the hypothalamus. The behavioural and physiological changes which ... -
Investigating management strategies of large litters in pigs
(The University of Edinburgh, 2019-06-29)Modern hyper-prolific sows often do not have enough teats to feed all of their piglets. The resulting competition for colostrum and milk hampers piglet growth and survival. This is exacerbated by low birth-weights, ... -
Lost pigs and broken genes: the search for causes of embryonic loss in the pig and the assembly of a more contiguous reference genome
(The University of Edinburgh, 2019-06-29)The pig is an economically important species, with pork being the most widely consumed meat in the world. Genomic technologies have the potential to improve reproduction, health and efficiency in the pig industry. ... -
Investigating the role of segment 3 in H9N2 avian influenza virus pathogenicity
(The University of Edinburgh, 209-06-29)H9N2 avian influenza viruses (AIV) are widespread in poultry populations worldwide, causing large economic losses. Reassortment events with other co-circulating AIV strains has led to an increased pathogenicity of H9N2 ... -
Bacterial host attribution and bioinformatic characterisation of enteric bacteria Salmonella enterica and Escherichia coli from different hosts and environments
(The University of Edinburgh, 2019-06-29)With the advent of relatively low cost whole genome sequencing (WGS), it is now possible to obtain sequences from large numbers of bacterial strains and interrogate their core and accessory genomes in relation to associated ... -
Cryptosporidiosis in calves
(The University of Edinburgh, 2019-06-29)Cryptosporidiosis is a widespread zoonotic parasitic disease affecting livestock all over the world. Despite its prevalence, there is very little evidence about transmission routes to young calves, and how it could affect ... -
Detection and characterisation of genetic associations with canine skull shape and disease
(The University of Edinburgh, 2019-06-29)The brachycephalic head conformation is a morphological trait under human selection across many popular breeds such as the Pug. The conformation is characterised by the concurrent rostrocaudal shortening and mediolateral ... -
Study of odontoclast dysregulation in feline tooth resorption
(The University of Edinburgh, 2019-06-29)Feline tooth resorption (TR) is a common and painful disease characterised by loss of mineralised tissues of the tooth. Due to the progressive nature of the disease the only available treatment is to extract affected ... -
Genotype-phenotype correlations in β-catenin
(The University of Edinburgh, 2019-06-29)Canonical Wnt signaling is one of the most extensively studied signaling cascades, with a multifunctional role in development and disease. Activating mutations in β-catenin, the key regulator of this pathway, have been ... -
Ontogeny of canine myxomatous mitral valve disease; cellular and molecular events over a lifetime
(The University of Edinburgh, 2019-06-29)Myxomatous mitral valve disease (MMVD) is the most common cardiac disease in dogs and the second most common cardiac valvular disease in humans. MMVD is particularly prevalent in small breed dogs (such as the Cavalier ... -
Transcriptomic analysis of sheep macrophages and their response to Lipopolysaccharide
(The University of Edinburgh, 2019-06-29)Sheep are ruminant animals, highly adapted to exploit pastures of low biological value and an economically important livestock species. They also provide a useful animal model for multiple areas of human medicine. Their ... -
Across-country dairy breeding strategies in sub-Saharan Africa
(The University of Edinburgh, 2019-06-29)Genetic improvement of livestock has a major impact on animal productivity and its effects are permanent, cumulative and usually highly cost effective. It is also of considerable potential value in countries, mostly in ... -
Molecular epidemiology of multi-drug resistant Escherichia coli in companion animal species
(The University of Edinburgh, 2019-06-29)This study focused on a group of multi-drug resistant (MDR) E. coli collected between 2002 and 2011 at the Small Animal Hospital, Royal (Dick) Veterinary School; isolated from urinary tract infections in dogs. The MDR ... -
Design and validation of an ex vivo, whole organ joint model using post mortem specimens
(The University of Edinburgh, 2019-06-29)Arthritis is a disease associated with high morbidity, affecting the quality of life of both human and veterinary patients. Therapeutic advances are aided by the use of in vivo rodent models however their translational ... -
Insights into the function and protein network of TALPID3
(The University of Edinburgh, 2019-06-29)More than 1500 proteins have been identified as centrosome or cilia proteins, however it is still unknown how these proteins form networks to control functions such as centrosome orientation, maturation and ciliogenesis. ...
