Bridging the gulf between microfluidics and high throughput industrial applications
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Date
26/11/2015Item status
Restricted AccessEmbargo end date
31/12/2100Author
Miller, Brian Maxdell
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Abstract
The use of biosensors and microfluidics devices is often limited by
constraints in terms of volumetric throughput due to the small dimensions of devices
in microfluidics and of expensive and complicated sample preparation steps
necessary to ensure the operation of biosensing platforms. This can be due to high
initial sample volume with low concentration analytes or complex media matrices
from which analytes are extracted. While working to analyse Cryptosporidium
presence in drinking water a novel technique was developed. The huge advantages
from using a label-free, buffer-free hydrodynamic mechanism in terms of cost,
coupled with the ease of simply scaling a single design to match any target size and
the ability manufacture these quickly and easily using cheap and readily available
robust materials (i.e. acrylic sheet) may allow a revolution in the scope of
microfluidics applications. Using a cascaded array of hydrodynamic focusing devices
uniquely designed for parallelised operation from a single pump or pressure source,
the array can be tailored to meet the specific requirements of many applications, in
particular high volume and low concentration target analyte enrichment from
complex media.