Edinburgh Medical School: Recent submissions
Now showing items 1-20 of 8321
-
Role of long non-coding RNA in atherosclerosis
(The University of Edinburgh, 2021-07-31)Coronary heart disease is responsible for around 2 million deaths across Europe each year. This is largely caused by atherosclerosis, a chronic inflammatory disease of the vasculature characterized by development of plaque ... -
Investigating the role of the tumour microenvironment and E-cadherin in Invasive Lobular Carcinoma
(The University of Edinburgh, 2021-07-31)Invasive lobular carcinoma (ILC) is the second most common histological subtype of breast cancer after invasive ductal carcinoma (IDC), which account for 10-15% and 80% of diagnosed breast cancers, respectively. ILC ... -
RIP 1 kinase inhibition for acute ischemic kidney injury
(The University of Edinburgh, 2020-11-30)Background: Acute ischemic kidney injury occurs in many clinical settings such as transplantation, major surgery, haemorrhage, dehydration and accounts for major mortality and morbidity in these settings. Acute kidney ... -
BronchStart Study Extended Data
(Wellcome Open Research (pending), 2021)Extended data for BronchStart Study Protocol. Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0). -
Examination of the community food environment and the drivers affecting and impacting obesogenicity in a deprived urban neighbourhood in Scotland
(The University of Edinburgh, 2020-11-30)Introduction: The condition of obesity has been classified as a pandemic , given that it is negatively impacted health in almost every country in the world (1). Scotland has one of the worst obesity records in the world ... -
Understanding the role of the long non-coding RNA MIR503HG in endothelial-to-mesenchymal transition during vascular remodelling
(The University of Edinburgh, 2020-11-30)Endothelial-to-mesenchymal transition (EndMT) is a dynamic biological process present during development and involved in a variety of pathological vascular remodelling scenarios. However, despite our growing understanding ... -
Glucose-lowering medication initiation in people with newly diagnosed type 2 diabetes in Scotland: a mixed-methods study
(The University of Edinburgh, 2020-11-30)Background: Worldwide, clinical guidelines recommend the reduction of glucose levels in people with type 2 diabetes mellitus (T2DM) as necessary in order to reduce risk of complications. In Scotland, the national guidelines ... -
Genetic underpinnings of adiposity: from GWAS discovery to functional characterisation
(The University of Edinburgh, 2020-11-30)Obesity affects more than 600 million people worldwide and causes 4 million excess deaths every year through its related co-morbidities, such as type 2 diabetes and heart disease. Detrimental anatomical distribution of ... -
Development of a human pluripotent stem cell-derived in vitro model of myelination
(The University of Edinburgh, 2020-11-30)Myelination is essential for central nervous system (CNS) formation, health, and function. Its development is an adaptive and regulated process that, when perturbed, leads to disease. However, our understanding of ... -
On the genetics of intermediate phenotypes and their utility
(The University of Edinburgh, 2020-07-27)The vast majority of common disease-associated genetic variation is non-coding. However, the route by which non-coding genetic variation influences disease susceptibility is largely unknown. The dissection of the genetic ... -
Bilingualism in autism: A neurocognitive investigation of the influence of bilingualism on perspective-taking in autistic adults
(The University of Edinburgh, 2020-11-30)Autism spectrum disorder (hereafter autism), is a lifelong neurodevelopmental condition with current prevalence estimates ranging around 1/100 worldwide. Autism is manifest in multiple forms, but always entails differences ... -
Studies with the bacteriophages of Escherichia coli
(The University of Edinburgh, 1966)In this Thesis a study is made of a number of episome-host relationships, with emphasis placed on use of the recombination-deficient bacterial cell as a new tool for examining the phenomena of transduction, lysogenization ... -
Establishing outer membrane Integrity in Klebsiella pneumoniae
(The University of Edinburgh, 2020-11-30)The Outer Membrane (OM) of Gram-negative bacteria is the primary barrier for the cell, with its asymmetric composition of lipopolysaccharides (LPS) at the outer leaflet and glycerophospholipids (GPL) at the inner ... -
Gene-environment interactions in relation to colorectal cancer risk
(The University of Edinburgh, 2020-11-30)Introduction: Colorectal cancer (CRC) is the third most common cancer by incidence and second by mortality worldwide in 2018. Variation in individual genetic susceptibility and environmental exposures both contribute to ... -
Neutrophils in advanced non-small cell lung cancer
(The University of Edinburgh, 2020-11-30)Lung cancer is the third most common cancer in the UK; 87% are histologically nonsmall cell lung cancer (NSCLC). At the time of diagnosis, patients frequently have advanced disease, with poor one-year survival due to ... -
Using mass spectrometry to profile sex steroids in metabolic diseases
(The University of Edinburgh, 2020-11-30)Sex hormones are steroids that are key co-ordinators of sexual development and are principally formed in endocrine glands. The main types of sex hormones in females are estrogens: notably estrone (E1) and estradiol ... -
Relationships between periodontal disease and oral health-related quality of life in the urban older population in Indonesia
(The University of Edinburgh, 2020-11-30)Improvement in prevention of disease and effective management of health are leading to increased life expectancy globally. This increased life expectancy is associated with challenges for the global public health in ... -
Gender inequities in health care utilisation for common infections children under-5 in India
(The University of Edinburgh, 2020-11-30)Common infectious diseases like pneumonia, diarrhoea and malaria, are the leading causes of mortality in young children aged below 5 years, especially in low and middle-income countries (LMICs). Globally, India is the ... -
Probing mechanisms by which cerebral vascular disease may influence cognitive impairment and dementia
(The University of Edinburgh, 2020-11-30)Introduction Vascular cognitive impairment (VCI) describes a full spectrum of cognitive deficits caused by underlying cerebral vascular alterations, regardless of the specific mechanisms involved. Several factors such ... -
A study of the Fife and Kinross District Asylum 1866-1899
(The University of Edinburgh, 1992)This thesis aims to illuminate the hitherto neglected area of the Scottish Victorian Pauper Asylum. It provides a detailed study of one specific institution, The Fife and Kinross District Asylum between the years 1866 ...
