Edinburgh Medical School: Recent submissions
Now showing items 1-20 of 8204
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Effect of manipulating PI3K pathway components on primordial follicle activation and DNA damage response in bovine ovarian follicles in vitro
(The University of Edinburgh, 2020-06-27)Developing immature follicles either from fresh or cryopreserved ovarian tissue to attain competent and fertilisable oocytes could provide an option for some patients undergoing fertility preservation to avoid the risk ... -
Constructing success in global health: the World Bank and the Onchocerciasis Control Programme in West Africa
(The University of Edinburgh, 2020-07-27)The Onchocerciasis Control Programme in West Africa (OCP), a United Nations-sponsored initiative that targeted a neglected tropical disease (NTD) from 1974-2002, has been depicted as a major global health success story ... -
DNA-mediated inflammation in pregnancy
(The University of Edinburgh, 2020-07-27)During pregnancy, the maternal immune system must adapt to allow for the growth of a semiallogenic fetus whilst maintaining the ability to respond to pathogens. Maternal immune system adaptions are imperfect. Pregnant ... -
Single cell transcriptomic analysis of autism associated gene expression in human cerebral cortex development
(The University of Edinburgh, 2020-08-07)Autism spectrum disorder (ASD) is a range of developmental brain disorders characterized by poor nonverbal communication skills, impaired behaviour and social interaction, and a limited diversity of social activities and ... -
Investigating the role of chromatin modifications in CRISPR/Cas9 gene editing
(The University of Edinburgh, 2020-07-27)Precisely positioned nucleosomes and heterochromatin have been shown to impede CRISPR/Cas9 editing efficiency. Conversely, Cas9 can open previously inaccessible regions of DNA, and transcriptionally silent targets ... -
Quantitative retinal traits and their association with cardiovascular disease and cardio-metabolic genetic variants in people with type 2 diabetes
(The University of Edinburgh, 2020-07-27)Introduction: Type 2 diabetes (T2D) is one of the most prevalent noncommunicable diseases in the world and its cardiovascular complications present a huge socio-economic burden. In 2015, in the UK alone, 3.8 million people ... -
Explaining how medical doctors learn about and understand the approach to the end-of-life in the workplace
(The University of Edinburgh, 2020-07-27)Background For patients approaching the end-of-life, treatments with life-prolonging intent can be futile, wasteful, and harmful. Equally, harm may be caused by prematurely treating patients as if they are dying. In ... -
Metabolic regulators of inflammation in acute pancreatitis
(The University of Edinburgh, 2020-07-27)Acute pancreatitis (AP) is a common inflammatory disease with multiple aetiological triggers, most commonly gallstones and alcohol consumption, but with no specific treatment. One in four patients with AP develop organ ... -
Optical profiling of macrophages
(The University of Edinburgh, 2020-07-27)Macrophages are required to show plasticity in how they react to their microenvironment and orchestrate an inflammatory response. With such an integral role in human immunity, aberrant macrophage function can directly ... -
Washington DC to New Delhi: the World Bank's influence in maternal and child health over the last five decades
(The University of Edinburgh, 2020-07-27)Introduction: The World Bank is one of the biggest external funders for maternal and child health in India and the world. Despite being a major actor in the global landscape for maternal and child health, there is ... -
Stratification of patient subgroups using high-dimensional and time-series observations
(The University of Edinburgh, 2020-07-27)Precision medicine and patient stratification are expanding as a result of innovations in high-throughput technologies applied to clinical medicine. Stratification can explain differences in disease trajectories and ... -
Exploring the role of central nervous system myelination in circuit function and behaviour
(The University of Edinburgh, 2020-08-07)Activity-mediated myelination, the adjustment of myelin morphology in response to neuronal activity, has been proposed as a novel mechanism of central nervous system (CNS) plasticity. As a key regulator of conduction ... -
Innate modifiers of T cell behaviour during inflammatory disease
(The University of Edinburgh, 2020-06-27)Neutrophils are the most abundant leukocyte in mammals and represent one of the first lines of defence against invading microorganisms. In recent years, it has become clear that neutrophils are not only responsible for ... -
Assessing neurodegeneration of the retina and brain with ultra-widefield retinal imaging
(The University of Edinburgh, 2020-06-27)The eye is embryologically, physiologically and anatomically linked to the brain. Emerging evidence suggests that neurodegenerative diseases, such as Alzheimer’s disease (AD), manifest in the retina. Retinal imaging is a ... -
Epidemiology of multimorbidity and polypharmacy in ageing: a complementary analysis of mental and brain health in three datasets
(The University of Edinburgh, 2020-06-27)Multimorbidity, the co-existence of two or more chronic conditions, is common and increasing in prevalence. It is associated with poor outcomes for patients and increased costs for healthcare providers, so is attracting ... -
Tentamen physiologicum inaugurale, de concoctione ciborum
(The University of Edinburgh, 1821)The boundaries between nature animals and plants placing the alimentary canal us The highest support. Zoophytes that bond to set up a connection between the two, it seems, endowed with a simple cavity, in which Absorption ... -
Germline genetic variations and survival outcomes of colorectal cancer
(The University of Edinburgh, 2020-06-27)BACKGROUND: Colorectal cancer (CRC) was the second commonest cancer and the third leading cause of cancer-related deaths worldwide in 2018. In the UK, the overall 5-year survival rate of CRC patients is approximately ... -
Critical assessment of computed tomography as a valid means of muscular body composition analysis in cancer cachexia
(The University of Edinburgh, 2020-06-27)Cancer cachexia is a constellation of symptoms affecting many cancer patients as their disease progresses. These include loss of muscle mass as well as function, and the utility of computed tomography (CT) in defining ... -
Investigating the relationship between SORCS2 and SORLA and DNA double-stranded break formation, as a possible mechanism in neuropsychiatric disorders
(The University of Edinburgh, 2020-06-27)SORCS2 and SORLA are members of the Vps10p-domain receptor family, which comprises five multifunctional neuronal receptors. All family members are involved in intracellular sorting and trafficking of various neurotrophic ... -
Functional characterisation of spontaneously active GABAA receptors in rat dentate gyrus granule cells
(The University of Edinburgh, 2020-06-27)GABAA receptors (GABAARs) are the principal inhibitory neurotransmitter receptors in the adult mammalian central nervous system. GABAARs mediate two forms of inhibition: fast, phasic conductance; and slow, tonic conductance. ...
