Edinburgh Medical School: Recent submissions
Now showing items 1-20 of 8465
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Novel mechanisms regulating the membrane recruitment of the ATG8 conjugation machinery
(The University of Edinburgh, 2021-07-31)Autophagy is a highly conserved eukaryotic process that maintains cell viability by targeting excess or damaged cytoplasmic material for lysosomal degradation. This process involves the generation of a double-membraned ... -
Breast cancer incidence and survival trends by molecular subtypes in Scotland
(The University of Edinburgh, 2021-07-31)Background: Breast cancer (BC) is the most common cancer among women and leading contributor to cancer mortality, hence constitutes a major public health issue worldwide. In Scotland, over 4,000 women are diagnosed ... -
Molecular and therapeutic stratification of endometrioid ovarian carcinoma
(The University of Edinburgh, 2021-07-31)Epithelial ovarian carcinomas (EOC) comprise five main histological subtypes, each displaying distinct pathological, molecular and clinical characteristics. Endometrioid ovarian carcinomas (EnOC) account for 10% of EOC ... -
Common genetic variance at the SMAD9 colorectal cancer risk locus influences tumour mutational phenotype
(The University of Edinburgh, 2021-07-31)I set out to investigate whether common germline variance associated with colorectal cancer (CRC) risk can influence the somatic mutational landscapes of CRC. Some Mendelian cancer syndromes, such as Lynch syndrome ... -
Reviewing people with Obstructive Sleep Apnoea Hypopnoea Syndrome: telehealth and templates
(The University of Edinburgh, 2021-07-31)Introduction Obstructive Sleep Apnoea Hypopnoea Syndrome (OSAHS) is estimated to affect one billion people globally, carrying a substantial risk of road traffic accidents due to daytime sleepiness with additional other ... -
Exploring how Japanese family physicians understand palliative care and identify patients for primary palliative care
(The University of Edinburgh, 2021-07-31)Background: Primary care clinicians have great potential to play a key role in providing palliative care in the community. However, difficulties in identifying patients for palliative care hinders progress. This problem ... -
New insights into probabilistic pattern formation of embryonic stem cells using agent-based modelling
(The University of Edinburgh, 2021-07-31)Embryonic stem cells (ESCs) hold great potential for developing future therapies for a wide range of diseases. However, the mechanisms of pattern formation during embryonic development remain poorly understood. ESCs in ... -
Allosteric regulation of the AAA+ superfamily protein reptin
(The University of Edinburgh, 2021-07-31)Reptin is a member of the AAA+ (adenosine triphosphatase associated with diverse cellular activities) protein superfamily with roles in many protein complexes and interactions which have been indicated in cancer including ... -
Role of IL6ST in endocrine sensitivity of breast cancer
(The University of Edinburgh, 2021-07-31)Breast cancer is the most common type and cause of cancer death in women. Oestrogen is a major growth stimulant of oestrogen receptor alpha (ERa) positive breast cancer and consequently, endocrine therapy which targets ... -
Role of perinatal inflammation in preterm brain injury
(The University of Edinburgh, 2021-07-31)Perinatal inflammation is associated with an increased risk of brain injury and neurodevelopmental impairment in preterm infants but the immune mediators driving this association are not well understood. This PhD thesis ... -
Manganese-enhanced magnetic resonance imaging of the myocardium
(The University of Edinburgh, 2021-07-31)Background Current clinical cardiac magnetic resonance imaging uses gadolinium contrast to detect myocardial pathology by characterising the extracellular space. Whilst a valuable clinical tool, gadolinium-based media ... -
Ascertainment, prediction and implications of dementia diagnosis in a study of 'healthy' cognitive ageing: the Lothian Birth Cohort 1921
(The University of Edinburgh, 2021-07-31)In the context of an ageing global population, dementia poses a significant public health challenge. While there is no cure, understanding the risks for dementia and how these may be minimised is key to reducing the ... -
Investigation of microRNAs as markers of human vascular dysfunction in kidney disease
(The University of Edinburgh, 2021-07-31)Vascular dysfunction commonly co-exists with kidney disease, which results in a substantially increased risk of cardiovascular disease (CVD). A severe, acute form of this vascular-renal phenotype is seen in those ... -
MicroRNAs as biomarkers in anti-tuberculosis drug-induced liver injury: a translational study from zebrafish to humans
(The University of Edinburgh, 2021-07-31)Drug-induced liver injury is one of the leading causes of acute liver failure and is a serious barrier to drug development. Furthermore, it is a frequent adverse reaction to the antimicrobials used to treat tuberculosis, ... -
Regulation of neural stem cell and glioblastoma stem cell quiescence by FOXG1 and Wnt/beta-catenin
(The University of Edinburgh, 2021-07-31)The balance of stem cell quiescence versus proliferation must be tightly regulated under normal homeostasis and becomes disrupted in cancers. The brain cancer glioblastoma is driven by cells with neural stem cell ... -
Investigating perfusion and hypoxia in the human uterus
(The University of Edinburgh, 2021-07-31)Abstract. Introduction: Heavy menstrual bleeding (HMB) is a common and debilitating condition. Current treatment options are limited by lack of effectiveness, side effects and surgical risks. Better understanding of the ... -
Characterisation of a novel rat model of cerebral small vessel disease with endothelial dysfunction and white matter change
(The University of Edinburgh, 2021-07-31)Cerebral small vessel disease (SVD) is the leading cause of vascular dementia and triples patients’ risk of stroke. The link between the blood-brain barrier and white matter changes in SVD is poorly understood but ... -
In-vitro exposure of blue light on retinal pigment epithelium and its relevance to age-related macular degeneration
(The University of Edinburgh, 2021-07-31)Age-related macular degeneration (AMD) is a complex disease arising from the interaction of multiple genes and environmental factors. AMD initially affects the pigmented monolayer in retina called retinal pigment epithelium ... -
Parental communication and infant language development: the influence of premature birth and socioeconomic risk
(The University of Edinburgh, 2021-07-31)Preterm birth is birth occurring before 37 weeks gestation. Preterm birth is associated with an increased risk of impairment in many neurodevelopmental outcomes, including a higher risk of later language impairment and ... -
Inter-organ signalling by hepatocyte-derived microRNA-122
(The University of Edinburgh, 2021-07-31)MicroRNAs (miRNAs) are small non-protein coding RNA species involved in the regulation of gene expression. Bound to either protein or encapsulated in extracellular vesicles (EVs), miRNA are released from the cell and ...
