Edinburgh Medical School: Recent submissions
Now showing items 1-20 of 7946
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Dysfunctional innate immunity in cystic fibrosis lung disease
(The University of Edinburgh, 2020-01-22)Cystic Fibrosis (CF) lung disease is characterised by dysfunctional innate immunity. Even before microbial colonisation is established, there is an accumulation of neutrophils within the airways. Neutrophil extracellular ... -
Role of the lactate receptor, GPR81, in renal haemodynamic physiology
(The University of Edinburgh, 2020-01-22)G protein-coupled receptor 81 (GPR81) is abundantly expressed in adipocytes where activation by the endogenous ligand lactate inhibits lipolysis. GPR81 is also found in non-adipose tissue but the receptor’s function here ... -
Role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease
(The University of Edinburgh, 2020-01-22)Chronic kidney disease (CKD) is a global disease affecting 10% of the world population and is largely treated by dialysis and organ transplant at late stages of disease. As rates of CKD rise, it is increasingly evident ... -
Role of HER-targeted tyrosine kinase inhibitors in the treatment of high grade serous ovarian cancer
(The University of Edinburgh, 2020-01-22)High-grade serous ovarian cancer (HGSOC) has the highest incidence rate of the various subtypes of ovarian cancer. HGSOC patients usually respond to initial platinum therapy, however approximately 70% of patients relapse, ... -
Genetics of multiple sclerosis in the Northern Isles of Scotland
(The University of Edinburgh, 2020-01-22)Multiple Sclerosis affects around 2 million people worldwide (Kantarci and Wingerchuk, 2006; Dutta and Trapp, 2011). The disease is typified by the destruction of the central nervous system neurons’ myelin sheaths, caused ... -
Investigating the role of eukaryotic translation elongation factor eEF1A2 in autism, epilepsy and intellectual disability
(The University of Edinburgh, 2020-01-22)Eukaryotic translation elongation factor eEF1A2 is responsible for delivering aminoacylated tRNAs to the ribosome during protein synthesis. Heterozygous de novo missense mutations in EEF1A2 have been identified in ... -
Investigating the protective properties of dimethyl fumarate and Nrf2 signalling in response to drug toxicity
(The University of Edinburgh, 2020-01-22)Liver disease represents a major cause of mortality and morbidity. Despite the regenerative capacity of the liver, maintained injury or acute injury can lead to loss of liver function and disease. The most common cause ... -
Intra-articular traumatic knee injuries
(The University of Edinburgh, 2019-12-06)Introduction: Tibial plateau and patellar fractures are common intra-articular fractures. An estimated 44% of patients develop post-traumatic arthritis (PTOA). PTOA is a disabling condition and the precise aetiology is ... -
Conserved temporal ordering of promoter activation implicates common mechanisms governing the immediate early response across cell types and stimuli
(The University of Edinburgh, 2019-12-06)The promoters of immediate early genes (IEGs) are rapidly activated in response to an external stimulus. These genes, also known as primary response genes, have been identified in a range of cell types, under ... -
Investigating the role of macrophages in the suppression of NK cell functions in mouse models of metastatic breast cancer
(The University of Edinburgh, 2020-06-27)Breast cancer is the leading cause of cancer-related death in females worldwide. Although 5-year survival of breast cancer patients in early stages is 89-100%, that of patients with metastatic tumours is reduced to just ... -
Analysis of visual images in examples of ‘encountered’ science communication
(The University of Edinburgh, 2020-01-21)Visual images are often used in science communication activities and events for different purposes and in different contexts. However, there is limited research on this area and the decision made for choosing a visual ... -
Expression of genes in the 16p11.2 locus during human fetal cortical neurogenesis
(The University of Edinburgh, 2020-01-22)The process of the brain developing from a single fertilized egg to the most sophisticated known organ requires precise spatial and temporal control to produce the necessary correct brain size and architecture. A particular ... -
Cardiovascular effects of the treatments for diabetes mellitus: the effect of SIRT-1 activation on markers of endothelial function, arterial stiffness and thrombosis; and the effect of hypoglycaemia on myocardial perfusion and biomarkers of ischaemia.
(The University of Edinburgh, 2020-01-22)Background. Both type 1 and type 2 diabetes mellitus are increasing in incidence and prevalence. Cardiovascular disease remains the number one cause of co-morbidity and mortality in this group of individuals. Intensive ... -
Understanding the heterogeneity of senescence and ageing at the single-cell level
(The University of Edinburgh, 2020-01-22)This thesis contains two main research projects, both of which demonstrate the power of singlecell approaches in the interrogation of complex biological systems. The first part of my studies focuses on cellular heterogeneity ... -
Investigating miR‐214 as a pro‐fibrotic mediator in renal fibrosis and its potential as a therapeutic target via effective in vivo modelling of chronic kidney disease
(The University of Edinburgh, 2020-01-22)Chronic kidney disease (CKD) is a prevalent health condition in the UK and worldwide. CKD is defined as the progressive decline of renal filtrative capacity over time. High rates of cardiovascular dysfunction and related ... -
Mechanisms to reverse impaired macrophage function in COPD
(The University of Edinburgh, 2020-06-01)COPD is major health problem and is set to become the third leading cause of death globally by 2030. To date we have no therapies which significantly alter the course of this debilitating disease. The lungs of COPD ... -
Relationship between lifestyle factors and neurodegeneration in midlife as expressed on arterial spin labelling and structural magnetic resonance imaging
(The University of Edinburgh, 2020-01-22)Introduction: Studies have demonstrated a relationship between neurodegeneration and lifestyle factors. Neurodegeneration in midlife (40 – 59 years old) can be assessed using neuroimaging. The aim of the thesis was to ... -
Hippo pathway regulates caveolae expression and mediates flow response via caveolae
(The University of Edinburgh, 2020-07-04)The Hippo pathway is a key regulator of cell survival, proliferation and tissue homeostasis. In addition, it is vital for development and regeneration. The activity of the Hippo pathway depends on intra- and extra-cellular ... -
Characterisation of Nrf2-signalling and the effects of boosting astrocytic Nrf2 in a mouse model of ischaemic stroke
(The University of Edinburgh, 2020-01-22)Stroke is the leading cause of disability for adults and the second leading cause of death worldwide. It is characterised by a sudden weakness or numbness of the face, arm or leg, most often on one side of the body. The ... -
Phenotyping outpatient exacerbations in bronchiectasis
(The University of Edinburgh, 2019-07-06)Bronchiectasis is a chronic respiratory condition with a wide spectrum of disease severity. There is a pressing need for randomised controlled trials in bronchiectasis to help guide management of this condition which is ...
