Edinburgh Medical School: Recent submissions
Now showing items 1-20 of 8663
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Investigation into the structural mechanisms underlying functional diversity of interferon-alpha subtypes
(The University of Edinburgh, 2022-05-23)Interferons (IFNs) were discovered by Isaacs and Lindeman in 1957, and were found to be the mediators of viral interference; as such they are central to innate immunity. They are expressed robustly upon recognition of viral ... -
Evaluating technologies in the assessment of pulmonary disease to aid lung transplantation: from ex vivo to in vivo models
(The University of Edinburgh, 2022-05-23)INTRODUCTION: Despite technological advances, the rate of utility of potential lung donors for transplantation remains low. As a consequence, more than a third of patients listed for lung transplant will not receive one. ... -
Investigating the structure and function of SAF-A
(The University of Edinburgh, 2022-05-23)SAF-A is a 90 kDa protein involved in the organisation of large-scale chromatin structure. SAF-A has four domains: a SAP domain with proposed DNA binding function, a SPRY domain of unknown function, an ATP binding domain ... -
Data-driven approach to identifying sub-types of adult asthma from primary care electronic health records
(The University of Edinburgh, 2022-05-04)Asthma is increasingly recognised as an umbrella term to describe a number of distinct clinical presentations (phenotypes) with underlying physiological mechanisms (endotypes). Numerous phenotypes and endotypes of asthma ... -
Computational framework for the discovery of retinal microvascular biomarkers of diabetes and renal disease
(The University of Edinburgh, 2022-05-04)The retina is a thin layer at the back of the eye unique in allowing easy observation of blood vessels using simple and non-invasive instruments. The visualisation of the in vivo vasculature using retinal imaging has ... -
Comprehensive accounting of lncRNA dynamics within vascular smooth muscle cell pathological transitions
(The University of Edinburgh, 2022-05-03)Vascular smooth muscle cells (VSMCs) provide vital contractile force within blood vessel walls, yet also propagate widespread cardiovascular pathologies with high mortality rates through pathological activities. The targeting ... -
The Molecular Determinants of Virulence in Crimean-Congo Hemorrhagic Fever Virus
(The University of Edinburgh, 2021-12-07)Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a tick borne nairovirus that is capable of causing a severe hemorrhagic disease in humans. The spectrum of disease caused by infection with CCHFV is extremely broad, with ... -
Developing automated meta-research approaches in the preclinical Alzheimer's disease literature
(The University of Edinburgh, 2022-04-28)Alzheimer’s disease is a devastating neurodegenerative disorder for which there is no cure. A crucial part of the drug development pipeline involves testing therapeutic interventions in animal disease models. However, ... -
Impact of environmental and genetic factors on pain sensitivity and chronic pain development
(The University of Edinburgh, 2022-04-27)Chronic pain is a significant clinical burden and available treatments are inadequate. Progress has been made in understanding and targeting underlying pain mechanisms but to target pain efficiently, we must understand why ... -
Scottish epilepsy-related deaths study (SEDS)
(The University of Edinburgh, 2022-04-22)INTRODUCTION: Epilepsy is a global condition associated with premature death. Although people with epilepsy (PWE) can die of causes unrelated to their epilepsy, many are thought to suffer increased risk of death because ... -
Prenatal anatomical and molecular changes in a mouse model of spinal muscular atrophy
(The University of Edinburgh, 2022-04-22)Spinal Muscular Atrophy (SMA) is monogenic disease caused by deletion of the Survival Motor Neuron 1 (SMN1) gene, with an incidence of about one in 10,000 live births. In the most severe and common type of SMA, symptoms ... -
mHealth for pneumonia prevention
(The University of Edinburgh, 2022-04-19)Pneumonia continues to be one of the leading killers of children under-five with 90,000 children dying annually in Pakistan attributed to delayed care-seeking for pneumonia secondary to impaired illness perception of ... -
To be or not to be: a critical realist exploration of factors motivating doctors in their commitment to improve their teaching practice in a clinical setting in Oman
(The University of Edinburgh, 2022-04-20)Adopting a critical realist framework, this study explored how medical doctors come to understand and espouse, or resist, their roles as teachers in clinical settings and how they seek to become more proficient in that ... -
Translating genetics into molecular pathways: revision of the 4p locus linkage for bipolar affective disorder and studying the effects of a copy number variation in DLG2 associated with schizophrenia
(The University of Edinburgh, 2022-04-20)The field of psychiatric genetics has identified several genes and molecular pathways as potentially implicated in the pathophysiology of major mental illness. This thesis describes two projects based on findings from ... -
Understanding the relationship between large-scale chromatin structure and gene expression
(The University of Edinburgh, 2022-04-19)Eukaryotic genomes are packaged into a complex DNA, RNA, and protein rich chromatin fibre, creating an interdependent functional relationship between the structure of the chromatin and the activity of the genetic features ... -
Management of Interests & External Interactions: A SPECTRUM Policy Document
(2022-03)The SPECTRUM Management of Interests and External Interactions document aims to make clear the official position of the Consortium with respect to engagement with external partners particularly where they may constitute, ... -
Role of multicellular organisation in mesoderm differentiation
(The University of Edinburgh, 2022-03-25)What cues and signals are important for the differentiation of pluripotent cells in vitro and in vivo? During development, pluripotent cell fate decisions are spatiotemporally coordinated with changing tissue architecture. ... -
Capturing the first haematopoietic stem cell: the needle in the haystack
(The University of Edinburgh, 2022-03-25)The most powerful cell in the blood differentiation hierarchy is the haematopoietic stem cell (HSC). It is the only cell capable of building an entire haematopoietic system from scratch, i.e. long-term (LT) repopulating a ... -
Presynaptic dysfunction in CDKL5 deficiency disorder
(The University of Edinburgh, 2022-03-25)Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a monogenic developmental and epileptic encephalopathy with onset in early infancy that is caused by mutations in the CDKL5 gene. CDD patients often exhibit ... -
Cellular responses to hydrostatic pressure and the role of the hippo pathway
(The University of Edinburgh, 2022-03-25)The ability of cells to respond to changes in mechanical forces in their microenvironment is critical for development, to respond to insults as well as for maintaining homeostasis. The Hippo Pathway and its downstream ...
