Edinburgh Medical School: Recent submissions
Now showing items 1-20 of 8809
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Establish the extended regulon of the RamA regulator by performing ChIPseq
(The University of Edinburgh, 2020-08-07)[No Deposit Agreement] -
Pro-regenerative role of tgfβ-1a after spinal cord injury in zebrafish larvae
(The University of Edinburgh, 2019-11-25)[No Deposit Agreement] -
Investigating outer membrane vesicular structure and function in Klebsiella pneumoniae
(The University of Edinburgh, 2019-10-25)[No Deposit Agreement] -
Clinical role of lung clearance index in the assessment of cystic fibrosis lung disease
(The University of Edinburgh, 2019-05-31)[No Deposit Agreement] -
Intestinal helminth infection and inflammatory responses in the murine brain
(The University of Edinburgh, 2019-06-29)Heligmosomoides polygyrus is a solely enteric helminth parasite that infects mice. It has recently been reported that infection of this parasite elicits a systemic increase in type-I interferon expression. This response ... -
Microglia regulate myelin growth and integrity in the central nervous system white matter
(The University of Edinburgh, 2023-01-30)Disruption of myelin structure occurs with ageing and neurodegenerative disease, and involves myelin which is outfolding, unravelling, less compact, and thicker. This is associated with nerve dysfunction and cognitive ... -
Pre-clinical screening for re-purposed and novel compounds that reduce synucleinopathy, and investigation of LRRK2 activity and VPS35 function within human cell culture models of Parkinson’s disease
(The University of Edinburgh, 2023-01-30)Human pluripotent stem cell (PSC) models of Parkinson’s disease (PD) are a promising tool for drug screening and for investigating disease mechanism. Mutations within LRRK2 are the most common cause of familial PD, where ... -
Role of FOXP1 in adipose progenitor maintenance during ageing
(The University of Edinburgh, 2023-01-27)Ageing is described as an inevitable functional decline over time, and is known to affect almost all living organisms. Adipose tissue (AT) has been viewed as a highly dynamic and adaptable organ and has been uncovered as ... -
Investigating the metabolic plasticity of inflammatory neutrophils during infection
(The University of Edinburgh, 2023-01-27)Neutrophils are required to function and survive under challenging conditions characterised by tissue hypoxia and nutrient scarcity. Neutrophils are well suited to rapidly respond to infection and engage with metabolic ... -
Investigating the genetic and immunological aetiology of myalgic encephalomyelitis/chronic fatigue syndrome
(The University of Edinburgh, 2023-01-25)This thesis describes two investigations into the disease Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), specifically its genetic aetiology and immune system alterations. The first study investigated the ... -
Health-related decision-making in its personal, social and health service contexts: a critical review of relevant findings from seven publications and consideration of their contribution to understandings of decision-making and the wider field of applied health services research
(The University of Edinburgh, 2023-01-25)Health-related decision-making, in particular patients’ involvement in decision-making about their treatment and care, has been an important and enduring concern for many practitioners and researchers working in applied ... -
In-depth enquiry into the implementation of a large-scale social health protection scheme in the context of the drive towards universal health coverage in Khyber Pakhtunkhwa, Pakistan
(The University of Edinburgh, 2023-01-24)BACKGROUND: In the wake of Goal 3 (ensuring healthy lives and promoting well-being for all at all ages) of the Sustainable Development Goals (SDGs) and the resulting push for Universal Health Coverage (UHC), Pakistan’s ... -
Role of ion channels in controlling murine corticotrophin excitability
(The University of Edinburgh, 2023-01-24)Anterior pituitary corticotrophs are integral components of the hypothalamus-pituitary-adrenal (HPA) axis controlling the neuroendocrine stress response. A variety of ion channels regulate intrinsic electrical excitability ... -
Do respiratory epithelial cells ‘remember’ early life microbial exposure through epigenetic changes?
(The University of Edinburgh, 2023-01-23)The adaptive immune system was considered to be the sole arm of immunity that can form a memory of past infections. In recent years this paradigm has been contested, following discoveries that many innate immune cells ... -
Resource use and costs at the end of life: essays on common ways to collect data on resource use and derive costs at the end of life in a UK setting
(The University of Edinburgh, 2023-01-19)BACKGROUND: Within the given environment of scarce health care resources and increasing demands on the health care system, it is imperative to organise health care in the most efficient manner. Sustainability of the overall ... -
Defining the role of neutrophils in paracetamol-induced liver injury and regeneration
(The University of Edinburgh, 2023-01-19)Neutrophils, the most abundant white blood cell in mammals, are crucial innate immune cells required as the first line of defence against invading pathogens or foreign material. They are also recruited in response to ... -
Characterisation of a model of ALS8 in the rat
(The University of Edinburgh, 2023-01-18)Amyotrophic lateral sclerosis 8 (ALS8) is a late-onset slow-progressing form of motor neurone disease caused by a missense mutation replacing cytosine with thymine in the VAMP-associated protein B (vapB) gene, leading to ... -
Molecular endotyping and integration with computer-aided CT imaging to stratify fibrotic lung disease
(The University of Edinburgh, 2023-01-17)Interstitial lung diseases (ILDs) are a conglomerate of disorders compounded by challenges in clinical diagnostic methods. The resulting patient groups are highly heterogenous with often unpredictable prognoses or responses ... -
Assessment of small vessel disease in human post-mortem tissue through radiology and histology
(The University of Edinburgh, 2023-01-16)Sporadic human cerebral small vessel disease (SVD) is a significant problem in our aging population. It is the most common cause of haemorrhagic stroke, causes one quarter of all ischaemic strokes, causes vascular dementia ... -
Primary cilia are essential for biliary regeneration following hypoxic injury
(The University of Edinburgh, 2023-01-12)BACKGROUND AND AIMS: Biliary complications (BC) are one of the most common complications following orthotopic liver transplantation (OLT). Up to 25% of OLT recipients will develop BC, a major factor determining long term ...
