Edinburgh Medical School: Recent submissions
Now showing items 1-20 of 8733
-
Dentine matrix proteins solubilised by 17% ethylenediaminetetraacetic acid and 7% maleic acid and their influence on human dental pulp stem cells: an in vitro study
(The University of Edinburgh, 2022-09-23)INTRODUCTION: Regenerative endodontic procedures have been practiced approximately over the past twenty years. These regenerate pulp-like tissue within the root canals of immature permanent teeth with pulpal necrosis which ... -
Recombinant complement factor H in complement-mediated diseases
(The University of Edinburgh, 2022-09-21)Complement Factor H (FH) is a 155-kDa plasma glycoprotein that regulates the alternative pathway of the complement system. Mutations or deficiencies in FH are associated with some cases of the kidney diseases C3 ... -
Investigating the role of R2TP-like co-chaperone complexes during axonemal dynein assembly
(The University of Edinburgh, 2022-09-02)Motile cilia are specialised cell-types which in humans have important roles in the linings of the airways, the reproductive system and the brain. The movement, required for this type of cilia to function, is facilitated ... -
Investigating the effects of 16p11.2 Microdeletion on progenitors and interneuron development using region-specific brain organoids
(The University of Edinburgh, 2022-09-02)Copy number variations (CNVs) of chromosomal region 16p11.2 are genetically linked to 1% of Autism Spectrum Disorder (ASD) cases. This 600kbp region contains 29 genes, but the functions of many genes in this CNV remain ... -
Investigating PAX6 and SOX2 dynamic interactions at the single molecule level in live cells
(The University of Edinburgh, 2022-09-01)The abundance of transcription factor (TF) molecules in the nuclei of eukaryotic cells are in the range of thousands. However, the functional binding sites of most TFs lie in the range of hundreds. This suggests that ... -
Overcoming barriers to cross-disciplinary research
(X-Net project, 2022-08)Interdisciplinary research can create many scientific opportunities but may also face challenges and barriers. X-Net’s main objective is helping interdisciplinary scientists to overcome those barriers providing guidance ... -
Investigating regulatory mechanisms for COL5A1 expression in the human cornea in health and disease
(The University of Edinburgh, 2022-08-01)Keratoconus is a complex corneal condition that is characterised by progressive corneal thinning and significant irregular astigmatism and eventual visual loss. The aetiology of keratoconus is not known although genetics ... -
Defining lineage plasticity of hepatic progenitor cells using transcriptomics and epigenomics
(The University of Edinburgh, 2022-08-01)Hepatocyte turnover becomes abrogated during chronic liver injury, resulting in an impaired liver function and the eventual onset of cirrhosis, only treatable with organ transplant. In this scenario of repeated damage, ... -
Macrophage WNT signalling in liver disease and regeneration
(The University of Edinburgh, 2022-08-30)Liver disease is still a clinical challenge. Even though the liver has a regenerative capacity, it can be impaired during acute or chronic injuries. Paracetamol overdose is the leading cause of acute liver injury ... -
Regulation of neutrophilic inflammation by the nutritional microenvironment
(The University of Edinburgh, 2022-08-30)Neutrophils are the most abundant leucocyte in blood and are rapidly recruited to sites of infection or injury to restore homeostasis. Such inflammatory sites are characterised by hypoxia and nutrient depletion and ... -
Adapting, evaluating and implementing pulmonary rehabilitation in Bangladesh
(The University of Edinburgh, 2022-08-22)[No Deposit Agreement] -
Multimethod examination of the status of emergency care in Ugandan health facilities
(The University of Edinburgh, 2022-08-17)Emergency care is a vital component of any functioning healthcare system, required to rapidly address a vast array of time-critical conditions and thereby reduce their associated morbidity and mortality. At present a wide ... -
Investigating the role of hippocampal-cortical circuits in memory, and their dysfunction in a rat model of Fragile X syndrome
(The University of Edinburgh, 2022-08-17)Place cells in the hippocampus form an internal spatial representation of an animal’s environment, which is thought to provide a basis for spatial and episodic memory. In order to form this representation, inputs from other ... -
Optimisation of gestational age estimates in low-income settings
(The University of Edinburgh, 2022-08-17)Accurate estimates of gestational age are fundamental to the provision of obstetric care, helping to facilitate appropriate antenatal care schedules and the identification and management of high-risk pregnancies. At a ... -
Exploring mechanisms of acquired taxane resistance in breast cancer
(The University of Edinburgh, 2022-08-16)Breast cancer is the most commonly diagnosed cancer globally and, despite advances in detection and improved treatment, it remains the leading cause of cancer death among women. Chemotherapy regimens include taxanes in ... -
Value of palliative care in newly diagnosed cancer
(The University of Edinburgh, 2022-07-01)INTRODUCTION: Globally, deaths due to non-communicable diseases are on the rise, with low- and middleincome countries (LMICs) particularly affected. Palliative care (PC) reduces pain and suffering for patients with ... -
Central pain processing in women with chronic pelvic pain syndrome
(The University of Edinburgh, 2022-06-30)Chronic pelvic pain (CPP) is chronic or persistent pain perceived in structures related to the pelvis of either men or women. It is often associated with negative cognitive, behavioural, sexual, and emotional consequences ... -
Mapping of glucocorticoids and aldosterone in mouse kidney using mass spectrometry imaging
(The University of Edinburgh, 2022-06-30)Renal sodium balance is the main regulator of blood pressure homeostasis. Sodium balance is regulated by aldosterone (ALDO) and, according to recent studies, also by glucocorticoids. Abnormal hormonal regulation of sodium ... -
Blood supply and innervation of the prostate: improving clinical outcomes after radical prostatectomy
(The University of Edinburgh, 2022-06-29)BACKGROUND: Radical prostatectomy remains the main choice of treatment for prostate cancer. However, despite improvements in surgical techniques and neurovascular sparing procedures, rates of erectile dysfunction and ... -
Analysis of the peritubular capillaries and lymphatics in a model of renal injury and repair
(The University of Edinburgh, 2022-06-29)[No Deposit Agreement]
