Edinburgh Medical School: Recent submissions
Now showing items 1-20 of 8862
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Application of machine learning methods to brain morphometry and connectivity data for major depressive disorder
(The University of Edinburgh, 2023-06-06)Major Depressive Disorder (MDD) is a common disabling psychiatric condition and is a major contributor to the overall global burden of disease. There are no biomarkers to aid the diagnosis of MDD, which currently relies ... -
Investigating the role of circulating cell-free dna as a mechanistic biomarker in inflammatory bowel disease: development of an integrated precision-medicine enabled platform in Scotland
(The University of Edinburgh, 2023-06-06)BACKGROUND: Circulating cell-free DNA (cfDNA) represents a class of biological molecules whose role in inflammation remains poorly understood. Inflammatory bowel disease (IBD), from ulcerative colitis to Crohn’s disease, ... -
Exploration of cord acid-base and glucose status of term and near-term infants, and oxygenation in preterm infants, with regard to mortality and clinically significant outcome
(The University of Edinburgh, 2023-05-24)This thesis comprises a series of studies initially focusing on the acid-base and glucose status of term and near-term infants at birth. It defines normal values and explores the influence on both short- and medium-term ... -
Probing PAX6-DNA interactions using high-throughput yeast one-hybrid assays and deep mutational scanning
(The University of Edinburgh, 2023-05-24)PAX6 is a highly conserved transcription factor essential for the correct development of the central nervous system, the pancreas, and the eye. Heterozygous deletions, nonsense, and frameshift mutations are generally ... -
Evaluation of the role of biomarkers in Alzheimer’s disease and age-related cognitive decline
(The University of Edinburgh, 2023-05-22)An ageing population will lead to an increase in age-related cognitive decline and dementia syndromes such as Alzheimer’s disease (AD), which can seriously limit an individual’s independence and quality of life. Identifying ... -
Anthropogenic and natural factors influencing the prevalence and persistence of antimicrobial resistance genes in the Scottish environment
(The University of Edinburgh, 2023-05-22)Antimicrobial resistance poses an ever-increasing threat to global health services. The environment is considered a major reservoir of antimicrobial resistance genes (ARGs), in large part due to anthropogenic pollution. ... -
Investigating trypanosome infection prevalence in three districts of Northern Uganda: a study of trypanosome populations in cattle and humans
(The University of Edinburgh, 2023-05-22)The African Trypanosomiases are a suite of diseases affecting humans and animals across sub-Saharan Africa, caused by protozoan trypanosome parasites and transmitted by tsetse flies (Glossina spp.). A number of different ... -
Melanoma cell plasticity: ALDH1A3 as a regulator of heterogeneity and therapeutic target
(The University of Edinburgh, 2023-05-19)Melanoma is the most lethal form of skin cancer. Melanoma heterogeneity not only roots from the genetic mutations, but also the distinct phenotypes driven by their special transcriptional state. Such plasticity allows the ... -
Evaluating participant-centred outcomes in clinical trials for motor neuron disease
(The University of Edinburgh, 2023-05-18)BACKGROUND: Motor neuron disease (MND), often referred to by its most common subtype amyotrophic lateral sclerosis (ALS) is a devastating and rapidly progressive neurodegenerative disorder for which there is no cure. ... -
Understanding the role of ontogeny for the development of infant MLL-AF9 leukaemia
(The University of Edinburgh, 2023-05-18)Infant leukaemia (0-1 years) remains a challenge in the clinic and is likely a reflection of a still developing understanding of its origins. Specific to infants with acute leukaemia is an in utero origin and a disproportionally ... -
RNAi screening identifies host determinants associated with susceptibility to respiratory virus infection
(The University of Edinburgh, 2023-05-15)Acute respiratory infections, especially those that lead to lower respiratory tract (LRI) complications, are a large public health concern worldwide. It is estimated that adults obtain a common cold or similar up to three ... -
Data-driven cross-validation to identify novel therapeutic targets in a diverse range of human diseases
(The University of Edinburgh, 2023-05-15)A common experimental output in biomedical science is a list of genes implicated in a given biological process or disease. Gene lists resulting from a group of studies answering the same, or similar, questions can be ... -
CTF19 complex ensures accurate chromosome segregation by directing multiple key processes during S. cerevisiae meiosis
(The University of Edinburgh, 2015)The segregation of homologous chromosomes during meiosis I is a key step in the formation of gametes. Proper segregation of homologs requires correct bipolar spindle attachment. However, how a cell monitors and achieves ... -
Cortisol dysregulation in equine endocrinopathic laminitis
(The University of Edinburgh, 2016-04-28)Laminitis is a common and severe disease of the horse's hoof occurring most frequently in association with the endocrine diseases Pituitary Pars Intermedia Dysfunction (PPID) or Equine Metabolic Syndrome (EMS) and referred ... -
Effect of maternal very severe obesity on maternal and offspring wellbeing and the influence of maternal glucocorticoids
(The University of Edinburgh, 2016-11-29)Globally one in five women are obese at antenatal booking, implying that many unborn infants are exposed to an obesogenic environment from very early in life. Obesity in pregnancy negatively affects both maternal and ... -
Application of data-driven technologies for asthma self-management
(The University of Edinburgh, 2023-05-02)INTRODUCTION: Asthma is a variable chronic condition, affecting around 5.4 million people in the UK and more than 300 million people worldwide. Every 10 seconds in the UK, someone has an asthma attack. Some of these attacks ... -
Preparing the Roadmap: "Prioritising cross-disciplinary training needs with industry" An X-Net workshop report
(X-Net, 2023-02)This workshop was part of the X-Net’s series of workshops to deliver on their goal to remove barriers for researchers crossing disciplines in the biomedical sciences. The main aims of this workshop were: i. explore how ... -
Cerebrovascular dysfunction in cerebral small vessel disease
(The University of Edinburgh, 2023-04-24)INTRODUCTION: Cerebral small vessel disease (SVD) is the cause of a quarter of all ischaemic strokes and is postulated to have a role in up to half of all dementias. SVD pathophysiology remains unclear but cerebrovascular ...
