Edinburgh Medical School: Recent submissions
Now showing items 1-20 of 8271
-
Neutrophils in advanced non-small cell lung cancer
(The University of Edinburgh, 2020-11-30)Lung cancer is the third most common cancer in the UK; 87% are histologically nonsmall cell lung cancer (NSCLC). At the time of diagnosis, patients frequently have advanced disease, with poor one-year survival due to ... -
Using mass spectrometry to profile sex steroids in metabolic diseases
(The University of Edinburgh, 2020-11-30)Sex hormones are steroids that are key co-ordinators of sexual development and are principally formed in endocrine glands. The main types of sex hormones in females are estrogens: notably estrone (E1) and estradiol ... -
Relationships between periodontal disease and oral health-related quality of life in the urban older population in Indonesia
(The University of Edinburgh, 2020-11-30)Improvement in prevention of disease and effective management of health are leading to increased life expectancy globally. This increased life expectancy is associated with challenges for the global public health in ... -
Gender inequities in health care utilisation for common infections children under-5 in India
(The University of Edinburgh, 2020-11-30)Common infectious diseases like pneumonia, diarrhoea and malaria, are the leading causes of mortality in young children aged below 5 years, especially in low and middle-income countries (LMICs). Globally, India is the ... -
Probing mechanisms by which cerebral vascular disease may influence cognitive impairment and dementia
(The University of Edinburgh, 2020-11-30)Introduction Vascular cognitive impairment (VCI) describes a full spectrum of cognitive deficits caused by underlying cerebral vascular alterations, regardless of the specific mechanisms involved. Several factors such ... -
A study of the Fife and Kinross District Asylum 1866-1899
(The University of Edinburgh, 1992)This thesis aims to illuminate the hitherto neglected area of the Scottish Victorian Pauper Asylum. It provides a detailed study of one specific institution, The Fife and Kinross District Asylum between the years 1866 ... -
Gonorrhœa virulenta
(The University of Edinburgh, 1823)Morbus, de quo in hoc opusculo, nempe Gonorrhoea, disserere statui, per longum tempus attentionem medici merito sibi attraxit; et multum inter se discrepant auctores, quoad viri naturam quod eam excitat. Multi et ... -
Effect of manipulating PI3K pathway components on primordial follicle activation and DNA damage response in bovine ovarian follicles in vitro
(The University of Edinburgh, 2020-06-27)Developing immature follicles either from fresh or cryopreserved ovarian tissue to attain competent and fertilisable oocytes could provide an option for some patients undergoing fertility preservation to avoid the risk ... -
Constructing success in global health: the World Bank and the Onchocerciasis Control Programme in West Africa
(The University of Edinburgh, 2020-07-27)The Onchocerciasis Control Programme in West Africa (OCP), a United Nations-sponsored initiative that targeted a neglected tropical disease (NTD) from 1974-2002, has been depicted as a major global health success story ... -
DNA-mediated inflammation in pregnancy
(The University of Edinburgh, 2020-07-27)During pregnancy, the maternal immune system must adapt to allow for the growth of a semiallogenic fetus whilst maintaining the ability to respond to pathogens. Maternal immune system adaptions are imperfect. Pregnant ... -
Single cell transcriptomic analysis of autism associated gene expression in human cerebral cortex development
(The University of Edinburgh, 2020-08-07)Autism spectrum disorder (ASD) is a range of developmental brain disorders characterized by poor nonverbal communication skills, impaired behaviour and social interaction, and a limited diversity of social activities and ... -
Investigating the role of chromatin modifications in CRISPR/Cas9 gene editing
(The University of Edinburgh, 2020-07-27)Precisely positioned nucleosomes and heterochromatin have been shown to impede CRISPR/Cas9 editing efficiency. Conversely, Cas9 can open previously inaccessible regions of DNA, and transcriptionally silent targets ... -
Quantitative retinal traits and their association with cardiovascular disease and cardio-metabolic genetic variants in people with type 2 diabetes
(The University of Edinburgh, 2020-07-27)Introduction: Type 2 diabetes (T2D) is one of the most prevalent noncommunicable diseases in the world and its cardiovascular complications present a huge socio-economic burden. In 2015, in the UK alone, 3.8 million people ... -
Explaining how medical doctors learn about and understand the approach to the end-of-life in the workplace
(The University of Edinburgh, 2020-07-27)Background For patients approaching the end-of-life, treatments with life-prolonging intent can be futile, wasteful, and harmful. Equally, harm may be caused by prematurely treating patients as if they are dying. In ... -
Metabolic regulators of inflammation in acute pancreatitis
(The University of Edinburgh, 2020-07-27)Acute pancreatitis (AP) is a common inflammatory disease with multiple aetiological triggers, most commonly gallstones and alcohol consumption, but with no specific treatment. One in four patients with AP develop organ ... -
Optical profiling of macrophages
(The University of Edinburgh, 2020-07-27)Macrophages are required to show plasticity in how they react to their microenvironment and orchestrate an inflammatory response. With such an integral role in human immunity, aberrant macrophage function can directly ... -
Washington DC to New Delhi: the World Bank's influence in maternal and child health over the last five decades
(The University of Edinburgh, 2020-07-27)Introduction: The World Bank is one of the biggest external funders for maternal and child health in India and the world. Despite being a major actor in the global landscape for maternal and child health, there is ... -
Stratification of patient subgroups using high-dimensional and time-series observations
(The University of Edinburgh, 2020-07-27)Precision medicine and patient stratification are expanding as a result of innovations in high-throughput technologies applied to clinical medicine. Stratification can explain differences in disease trajectories and ... -
Exploring the role of central nervous system myelination in circuit function and behaviour
(The University of Edinburgh, 2020-08-07)Activity-mediated myelination, the adjustment of myelin morphology in response to neuronal activity, has been proposed as a novel mechanism of central nervous system (CNS) plasticity. As a key regulator of conduction ... -
Innate modifiers of T cell behaviour during inflammatory disease
(The University of Edinburgh, 2020-06-27)Neutrophils are the most abundant leukocyte in mammals and represent one of the first lines of defence against invading microorganisms. In recent years, it has become clear that neutrophils are not only responsible for ...
