Edinburgh Medical School thesis and dissertation collection: Recent submissions
Now showing items 1-20 of 8557
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Multimethod examination of the status of emergency care in Ugandan health facilities
(The University of Edinburgh, 2022-08-17)Emergency care is a vital component of any functioning healthcare system, required to rapidly address a vast array of time-critical conditions and thereby reduce their associated morbidity and mortality. At present a wide ... -
Investigating the role of hippocampal-cortical circuits in memory, and their dysfunction in a rat model of Fragile X syndrome
(The University of Edinburgh, 2022-08-17)Place cells in the hippocampus form an internal spatial representation of an animal’s environment, which is thought to provide a basis for spatial and episodic memory. In order to form this representation, inputs from other ... -
Optimisation of gestational age estimates in low-income settings
(The University of Edinburgh, 2022-08-17)Accurate estimates of gestational age are fundamental to the provision of obstetric care, helping to facilitate appropriate antenatal care schedules and the identification and management of high-risk pregnancies. At a ... -
Exploring mechanisms of acquired taxane resistance in breast cancer
(The University of Edinburgh, 2022-08-16)Breast cancer is the most commonly diagnosed cancer globally and, despite advances in detection and improved treatment, it remains the leading cause of cancer death among women. Chemotherapy regimens include taxanes in ... -
Value of palliative care in newly diagnosed cancer
(The University of Edinburgh, 2022-07-01)INTRODUCTION: Globally, deaths due to non-communicable diseases are on the rise, with low- and middleincome countries (LMICs) particularly affected. Palliative care (PC) reduces pain and suffering for patients with ... -
Central pain processing in women with chronic pelvic pain syndrome
(The University of Edinburgh, 2022-06-30)Chronic pelvic pain (CPP) is chronic or persistent pain perceived in structures related to the pelvis of either men or women. It is often associated with negative cognitive, behavioural, sexual, and emotional consequences ... -
Mapping of glucocorticoids and aldosterone in mouse kidney using mass spectrometry imaging
(The University of Edinburgh, 2022-06-30)Renal sodium balance is the main regulator of blood pressure homeostasis. Sodium balance is regulated by aldosterone (ALDO) and, according to recent studies, also by glucocorticoids. Abnormal hormonal regulation of sodium ... -
Blood supply and innervation of the prostate: improving clinical outcomes after radical prostatectomy
(The University of Edinburgh, 2022-06-29)BACKGROUND: Radical prostatectomy remains the main choice of treatment for prostate cancer. However, despite improvements in surgical techniques and neurovascular sparing procedures, rates of erectile dysfunction and ... -
Analysis of the peritubular capillaries and lymphatics in a model of renal injury and repair
(The University of Edinburgh, 2022-06-29)[No Deposit Agreement] -
Exploration of the role of smoking in the lives of young people from a disadvantaged community in Glasgow
(The University of Edinburgh, 2022-07-08)Smoking prevalence has significantly declined in Scotland over the past two decades. However, pockets of high smoking prevalence remain which are socially and spatially patterned. Thirty-two percent of adults in the most ... -
Novel imaging and blood biomarkers in acute aortic syndrome
(The University of Edinburgh, 2022-06-29)BACKGROUND: Acute aortic syndrome is an unpredictable and catastrophic condition. It is characterised by medial degeneration which is beyond the resolution of conventional anatomical imaging. Here, we investigate 18F-sodium ... -
Parent and patient perspective of fatal and near-fatal asthma
(The University of Edinburgh, 2022-06-29)INTRODUCTION: Asthma is one of the most common long term conditions, typically affecting 1 in 11 children and 1 in 12 adults within the UK. Although asthma attacks are common, near-fatal asthma attacks and asthma deaths ... -
Imaging microcalcium in thoracic aortic disease
(The University of Edinburgh, 2022-06-29)BACKGROUND: Disease of the thoracic aorta occurs in two major forms; atheroma and aneurysm formation. Both disease processes progress silently before catastrophic complications occur, such as stroke or aortic dissection. ... -
Management of early medical abortion
(The University of Edinburgh, 2022-06-29)BACKGROUND: Unintended pregnancy is common. Many of these pregnancies end in abortion. Abortion is increasingly performed at earlier gestations and using medical methods, that is through administration of the medications ... -
Impact of oral health on diet among the ageing population in Saudi Arabia
(The University of Edinburgh, 2022-06-28)BACKGROUND: In older adults, there are many factors that determine dietary intake, including an individual's socio-economic status, physical well-being, and general state of health. Another crucial factor is dental status. ... -
Mouse-derived cerebral organoids as a tool for investigating the role of Foxg1 in forebrain development
(The University of Edinburgh, 2022-06-28)The formation of the mammalian forebrain is a highly complex process requiring the precise interplay of numerous factors. One such factor is the gene Foxg1 which begins to be expressed at the very earliest stages of ... -
Synaptome maps change with circadian rhythms, the sleep-wake cycle and sleep deprivation
(The University of Edinburgh, 2022-06-27)Understanding how circadian rhythms and vigilance states affect memory and synaptic plasticity is of major interest in biology. Their effects on the structural synaptic plasticity of the mouse brain have been investigated ... -
Transcription factor Pax6 protects mouse cortical cell fate specification
(The University of Edinburgh, 2022-06-27)The mammalian cortex is composed of two main types of neuron. Principal cells (PCs) are glutamatergic and use glutamate as the main neurotransmitter. Interneurons are mostly GABAergic and use GABA as their main neurot ... -
Embracing heterogeneity in multi-donor scRNAseq data: scalable inference of multi-scale heterogenity
(The University of Edinburgh, 2022-06-23)Heterogeneity in gene expression is a characteristic of cell populations that has been linked to disease, development, tissue homeostasis, and immune function. Single cell RNA sequencing technologies have enabled researchers ... -
Preclinical risk of bias assessment and PICO extraction using natural language processing
(The University of Edinburgh, 2022-06-23)Drug development starts with preclinical studies which test the efficacy and toxicology of potential candidates in living animals, before proceeding to clinical trials examined on human subjects. Many drugs shown to be ...
