Edinburgh Medical School thesis and dissertation collection: Recent submissions
Now showing items 1-20 of 8232
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Production of a synthetic superenhancer to monitor SOX2 transcriptional activity in glioblastoma
(The University of Edinburgh, 2021-07-31)Glioblastoma (GBM) is the most common adult brain cancer and one of the most lethal human cancers. SOX2-expressing GBM cells drive tumour growth and have a neural stem cell-like identity. Here, we developed novel ... -
Characterisation and mechanisms of altered body composition and tissue wasting in cancer cachexia
(The University of Edinburgh, 2020-11-30)Cancer cachexia has been defined as a multifactorial syndrome characterised by an ongoing loss of skeletal muscle that cannot be fully reversed by conventional nutritional support. Cachexia affects most patients with ... -
Investigating the renal and vascular mechanisms of salt-induced hypertension in C57BL6/J mice
(The University of Edinburgh, 2020-11-30)Dietary salt intake has a detrimental relationship with blood pressure (BP); the more salt consumed per day, the higher the incidence of hypertension and its cardiorenal consequences within a population. However, the ... -
Improving communication and shared decision making after major stroke: a mixed methods study
(The University of Edinburgh, 2020-11-30)Introduction Patients may be significantly disabled after a major stroke but two patients in the same disability level according to outcome scales such as the modified Rankin scale (mRs) can vary with respect to their ... -
Bilingualism in autism: a neurocognitive investigation of the influence of bilingualism on perspective-taking in autistic adults
(The University of Edinburgh, 2020-11-30)Autism spectrum disorder (hereafter autism), is a lifelong neurodevelopmental condition with current prevalence estimates ranging around 1/100 worldwide. Autism is manifest in multiple forms, but always entails differences ... -
Effect of insults associated with preterm birth on mouse brain development
(The University of Edinburgh, 2020-11-30)Preterm birth (PTB) is associated with an increased incidence of many neurodevelopmental disorders. The mechanisms underlying this association are unclear, but insults associated with PTB such as hypoxia, inflammation ... -
Impact of hypoxia on remyelination in a mouse model of Multiple Sclerosis
(The University of Edinburgh, 2020-11-30)Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), characterised by focal areas of myelin destruction (demyelination), oligodendrocyte death with variable extent ... -
Cellular and circuit excitability in rodent models of neurodevelopmental disorders
(The University of Edinburgh, 2020-11-30)Autism spectrum disorders and intellectual disabilities (ASD/ID) are estimated to a↵ect approximately 3-5% of the population. Genetic factors constitute a major risk factor in ASD/ID, accounting for 40 to 50% of cases, ... -
Human lifespan: recent trends and genetic determinants
(The University of Edinburgh, 2020-11-30)Human lifespan is determined by a complex interplay of genetics, environment, lifestyle and chance. In the UK, life expectancy has increased by roughly three years every decade, but despite longer lives, individuals ... -
Investigating how neuronal activity state governs the decline of plasticity with age in C. elegans
(The University of Edinburgh, 2020-11-30)Neural plasticity, which is the basis or learning and memory formation, declines continuously and progressively over the course of life. However, the molecular mechanisms underlying neuronal ageing and the decline of ... -
Social media narratives in non-communicable disease: their dynamics and value for patients, communities and health researchers
(The University of Edinburgh, 2020-11-30)Background: Usage of social media is now widespread and growing, as is the number of people living with Non-Communicable Diseases (NCDs) such as diabetes and cancer. This thesis examines how social media are being used to ... -
Role of ethnicity in framing childhood obesity as a public health problem
(The University of Edinburgh, 2020-11-30)The prevalence of overweight and obesity in children and adults has risen to alarming levels across the world and is also markedly increasing in developing countries. In Colombia, a multi-ethnic country, the prevalence ... -
Linking mitochondrial metabolism and macrovesicular steatosis in non-alcoholic fatty liver disease
(The University of Edinburgh, 2020-11-30)Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of liver disease globally, affecting approximately 88% of obese individuals. It is characterised by hepatic lipid accumulation >5%, which can lead ... -
Morphological analysis of the Axon Initial Segment in novel monogenic rat models of Autism Spectrum Disorder and Intellectual Disability
(The University of Edinburgh, 2020-11-30)Monogenic mutations in synaptic proteins are known to cause severe and low functioning cases of autism spectrum disorder and intellectual disability (ASD/ID) (Wright et al., 2018). One of the most prevalent monogenic ... -
Predicting outcome in Crohn’s disease
(The University of Edinburgh, 2020-11-30)Crohn’s disease is a chronic immune-mediated disease which can cause inflammation in the gastrointestinal tract anywhere between mouth and anus. It is now understood to be the result of a complex interplay between ... -
Fear behaviour and its underlying physiology in the Nlgn3⁻/ʸ rat model of autism
(The University of Edinburgh, 2020-11-30)Neurodevelopmental disorders, including autism spectrum disorder (ASD) and intellectual disabilities (IDs), are a heterogeneous range of disorders thought to affect approximately 3-5 % of the population. There are currently ... -
Resting state functional magnetic resonance imaging in Fragile X syndrome
(The University of Edinburgh, 2020-11-30)Autism Spectrum Disorders (ASD) and Intellectual Disabilities (ID) are two co-occurring neurodevelopmental disorders that affect approximately 100 million individuals worldwide, making them leading causes of disability in ... -
Diagnostic stability in subjects with multiple admissions for psychotic illness
(The University of Edinburgh, 1999-07)This study describes the demographic, admission and diagnostic characteristics of a group of 204 subjects from the Royal Edinburgh Hospital who received exit diagnoses according to the functional psychoses over the 2 ... -
Synthetic cell-based patterning systems and their applications in stem cell differentiation
(The University of Edinburgh, 2020-11-30)Pattern formation underpins cell specification, tissue organization, and morphogenesis during embryonic development. Tissue engineering strategies based on stem cell differentiation and organoid formation attempt to ...
