Edinburgh Medical School thesis and dissertation collection: Recent submissions
Now showing items 1-20 of 8637
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Investigating the genetic and immunological aetiology of myalgic encephalomyelitis/chronic fatigue syndrome
(The University of Edinburgh, 2023-01-25)This thesis describes two investigations into the disease Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), specifically its genetic aetiology and immune system alterations. The first study investigated the ... -
Health-related decision-making in its personal, social and health service contexts: a critical review of relevant findings from seven publications and consideration of their contribution to understandings of decision-making and the wider field of applied health services research
(The University of Edinburgh, 2023-01-25)Health-related decision-making, in particular patients’ involvement in decision-making about their treatment and care, has been an important and enduring concern for many practitioners and researchers working in applied ... -
In-depth enquiry into the implementation of a large-scale social health protection scheme in the context of the drive towards universal health coverage in Khyber Pakhtunkhwa, Pakistan
(The University of Edinburgh, 2023-01-24)BACKGROUND: In the wake of Goal 3 (ensuring healthy lives and promoting well-being for all at all ages) of the Sustainable Development Goals (SDGs) and the resulting push for Universal Health Coverage (UHC), Pakistan’s ... -
Role of ion channels in controlling murine corticotrophin excitability
(The University of Edinburgh, 2023-01-24)Anterior pituitary corticotrophs are integral components of the hypothalamus-pituitary-adrenal (HPA) axis controlling the neuroendocrine stress response. A variety of ion channels regulate intrinsic electrical excitability ... -
Do respiratory epithelial cells ‘remember’ early life microbial exposure through epigenetic changes?
(The University of Edinburgh, 2023-01-23)The adaptive immune system was considered to be the sole arm of immunity that can form a memory of past infections. In recent years this paradigm has been contested, following discoveries that many innate immune cells ... -
Resource use and costs at the end of life: essays on common ways to collect data on resource use and derive costs at the end of life in a UK setting
(The University of Edinburgh, 2023-01-19)BACKGROUND: Within the given environment of scarce health care resources and increasing demands on the health care system, it is imperative to organise health care in the most efficient manner. Sustainability of the overall ... -
Defining the role of neutrophils in paracetamol-induced liver injury and regeneration
(The University of Edinburgh, 2023-01-19)Neutrophils, the most abundant white blood cell in mammals, are crucial innate immune cells required as the first line of defence against invading pathogens or foreign material. They are also recruited in response to ... -
Characterisation of a model of ALS8 in the rat
(The University of Edinburgh, 2023-01-18)Amyotrophic lateral sclerosis 8 (ALS8) is a late-onset slow-progressing form of motor neurone disease caused by a missense mutation replacing cytosine with thymine in the VAMP-associated protein B (vapB) gene, leading to ... -
Molecular endotyping and integration with computer-aided CT imaging to stratify fibrotic lung disease
(The University of Edinburgh, 2023-01-17)Interstitial lung diseases (ILDs) are a conglomerate of disorders compounded by challenges in clinical diagnostic methods. The resulting patient groups are highly heterogenous with often unpredictable prognoses or responses ... -
Assessment of small vessel disease in human post-mortem tissue through radiology and histology
(The University of Edinburgh, 2023-01-16)Sporadic human cerebral small vessel disease (SVD) is a significant problem in our aging population. It is the most common cause of haemorrhagic stroke, causes one quarter of all ischaemic strokes, causes vascular dementia ... -
Primary cilia are essential for biliary regeneration following hypoxic injury
(The University of Edinburgh, 2023-01-12)BACKGROUND AND AIMS: Biliary complications (BC) are one of the most common complications following orthotopic liver transplantation (OLT). Up to 25% of OLT recipients will develop BC, a major factor determining long term ... -
Applying state of the art technologies in the zebrafish to elucidate the mechanisms underpinning cardiovascular regeneration
(The University of Edinburgh, 2023-01-12)While the adult mammalian heart lacks the ability to undergo regeneration following injury, both larval and adult zebrafish can fully recover from a range of cardiac insults. Over the past two decades, our understanding ... -
Prediction and properties of missense variants in proteins
(The University of Edinburgh, 2023-01-10)[No Deposit Agreement] -
Investigating the role of microglia in cortical synaptic pathology in multiple sclerosis and animal models of cortical demyelination
(The University of Edinburgh, 2022-12-22) -
Respiratory microbiota: interactions with maternal pneumococcal immunisation and live attenuated influenza vaccine (LAIV) in children
(The University of Edinburgh, 2022-12-22)Respiratory tract infections (RTIs) are a leading cause of mortality in children under five years. The high burden of RTIs is experienced in low and middle-income countries (LMICs). RTIs are caused by bacteria and ... -
Characterisation of the Ugandan HIV epidemic with full-length genome sequence data from 1986 to 2016
(The University of Edinburgh, 2022-12-22)Presented here are two large Ugandan HIV genome datasets, one from the modern period (by the MRC/UVRI & LSHTM group and PANGEA), and another generated from stored 1986 serum samples using target-capture next generation ... -
Development, assessment and in vivo results of a novel ultrasound imaging technique for lymph node staging in a mouse model of metastasis
(The University of Edinburgh, 2022-12-21)Cancer is the second leading cause of death worldwide, responsible for 1 in 6 deaths in 2018 (9.6 million deaths)(World Health Organization, 2017). Early detection is of upmost importance to increase patients’ chances of ... -
Improving diagnosis in acute cardiac care using statistical machine learning
(The University of Edinburgh, 2022-12-20)Cardiovascular disease affects more than half of people in the United Kingdom and remains the most common cause of death. Each year more than 25 million persons attend an Emergency Department, with chest pain or breathlessness ... -
Epigenetic and population-based approaches to studying the association between socioeconomic status and depression risk
(The University of Edinburgh, 2022-12-20)AIMS: Depression is a common mental disorder and the leading cause of disability world-wide (GBD 2018). With heritability measures around 37% (Sullivan, Neale, & Kendler, 2000), most of the risk for developing depression ... -
Systematising and scaling literature curation for genetically determined developmental disorders
(The University of Edinburgh, 2022-12-19)The widespread availability of genomic sequencing has transformed the diagnosis of genetically-determined developmental disorders (GDD). However, this type of test often generates a number of genetic variants, which have ...
