Edinburgh Medical School thesis and dissertation collection: Recent submissions
Now showing items 1-20 of 8706
-
Characterizing novel gene therapy vectors to identify a potential promising new treatment for Fragile X Syndrome
(The University of Edinburgh, 2023-06-09)INTRODUCTION: Fragile X Syndrome (FXS) is an X-chromosome linked, neurodevelopmental disorder, which is caused by the silencing of the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene that encodes the Fragile X ... -
Factors associated with using a care home for older people living in Scotland: analyses using linked administrative data
(The University of Edinburgh, 2023-06-09)BACKGROUND: Scotland has an ageing population, so an increasing responsibility for old age social care. Research elsewhere has demonstrated that several socio-demographic, geographical and health factors predict entry ... -
Longevity of the health benefits of breast reduction
(The University of Edinburgh, 2023-06-09)Aesthetic surgery is available to a small number of patients of patients on the National Health Service (NHS) in Scotland, chosen from a large number of individuals who are referred for various procedures. The most popular ... -
Apelin as a potential treatment for chronic kidney disease
(The University of Edinburgh, 2023-06-07)Chronic kidney disease (CKD) is a global health emergency. It affects ~10% of the global population, and cardiovascular disease is its commonest endpoint. Current standard of care treatment involves using blockers of ... -
Development and pilot testing of health worker delivered theory of planned behaviour based educational intervention for behaviour change in chronic respiratory disease patients: a feasibility study in southern Indian rural community
(The University of Edinburgh, 2023-06-07)INTRODUCTION: Chronic respiratory diseases (CRDs) are one of the major causes of mortality and morbidity worldwide. Low- and middle-income countries (LMICs) account for 80% of the total burden of CRDs and mortality. CRDs ... -
Ectopic pregnancy: models and medical management
(The University of Edinburgh, 2023-06-07)Ectopic pregnancy, derived from the Greek “ektopos” meaning ‘out-of-place’, describes a pregnancy where the conceptus implants and develops at an abnormal location, most commonly the Fallopian tube. It complicates 1-2% ... -
Role of PABP4 in intrauterine growth restriction
(The University of Edinburgh, 2023-06-06)In mammals, two members of the poly(A)-binding protein (PABP) family of RNAbinding proteins, PABP1 and PABP4, are widely expressed in a range of adult tissues. PABP1, the prototypical family member, has been intensively ... -
Application of machine learning methods to brain morphometry and connectivity data for major depressive disorder
(The University of Edinburgh, 2023-06-06)Major Depressive Disorder (MDD) is a common disabling psychiatric condition and is a major contributor to the overall global burden of disease. There are no biomarkers to aid the diagnosis of MDD, which currently relies ... -
Investigating the role of circulating cell-free dna as a mechanistic biomarker in inflammatory bowel disease: development of an integrated precision-medicine enabled platform in Scotland
(The University of Edinburgh, 2023-06-06)BACKGROUND: Circulating cell-free DNA (cfDNA) represents a class of biological molecules whose role in inflammation remains poorly understood. Inflammatory bowel disease (IBD), from ulcerative colitis to Crohn’s disease, ... -
Exploration of cord acid-base and glucose status of term and near-term infants, and oxygenation in preterm infants, with regard to mortality and clinically significant outcome
(The University of Edinburgh, 2023-05-24)This thesis comprises a series of studies initially focusing on the acid-base and glucose status of term and near-term infants at birth. It defines normal values and explores the influence on both short- and medium-term ... -
Probing PAX6-DNA interactions using high-throughput yeast one-hybrid assays and deep mutational scanning
(The University of Edinburgh, 2023-05-24)PAX6 is a highly conserved transcription factor essential for the correct development of the central nervous system, the pancreas, and the eye. Heterozygous deletions, nonsense, and frameshift mutations are generally ... -
Evaluation of the role of biomarkers in Alzheimer’s disease and age-related cognitive decline
(The University of Edinburgh, 2023-05-22)An ageing population will lead to an increase in age-related cognitive decline and dementia syndromes such as Alzheimer’s disease (AD), which can seriously limit an individual’s independence and quality of life. Identifying ... -
Anthropogenic and natural factors influencing the prevalence and persistence of antimicrobial resistance genes in the Scottish environment
(The University of Edinburgh, 2023-05-22)Antimicrobial resistance poses an ever-increasing threat to global health services. The environment is considered a major reservoir of antimicrobial resistance genes (ARGs), in large part due to anthropogenic pollution. ... -
Investigating trypanosome infection prevalence in three districts of Northern Uganda: a study of trypanosome populations in cattle and humans
(The University of Edinburgh, 2023-05-22)The African Trypanosomiases are a suite of diseases affecting humans and animals across sub-Saharan Africa, caused by protozoan trypanosome parasites and transmitted by tsetse flies (Glossina spp.). A number of different ... -
Melanoma cell plasticity: ALDH1A3 as a regulator of heterogeneity and therapeutic target
(The University of Edinburgh, 2023-05-19)Melanoma is the most lethal form of skin cancer. Melanoma heterogeneity not only roots from the genetic mutations, but also the distinct phenotypes driven by their special transcriptional state. Such plasticity allows the ... -
Evaluating participant-centred outcomes in clinical trials for motor neuron disease
(The University of Edinburgh, 2023-05-18)BACKGROUND: Motor neuron disease (MND), often referred to by its most common subtype amyotrophic lateral sclerosis (ALS) is a devastating and rapidly progressive neurodegenerative disorder for which there is no cure. ... -
Understanding the role of ontogeny for the development of infant MLL-AF9 leukaemia
(The University of Edinburgh, 2023-05-18)Infant leukaemia (0-1 years) remains a challenge in the clinic and is likely a reflection of a still developing understanding of its origins. Specific to infants with acute leukaemia is an in utero origin and a disproportionally ... -
RNAi screening identifies host determinants associated with susceptibility to respiratory virus infection
(The University of Edinburgh, 2023-05-15)Acute respiratory infections, especially those that lead to lower respiratory tract (LRI) complications, are a large public health concern worldwide. It is estimated that adults obtain a common cold or similar up to three ... -
Data-driven cross-validation to identify novel therapeutic targets in a diverse range of human diseases
(The University of Edinburgh, 2023-05-15)A common experimental output in biomedical science is a list of genes implicated in a given biological process or disease. Gene lists resulting from a group of studies answering the same, or similar, questions can be ...
