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dc.contributor.advisorAustin, Elizabeth
dc.contributor.advisorShenkin, Susan
dc.contributor.advisorStarr, John
dc.contributor.authorMcGrory, Sarah
dc.date.accessioned2016-08-24T10:31:39Z
dc.date.available2016-08-24T10:31:39Z
dc.date.issued2015-06-30
dc.identifier.urihttp://hdl.handle.net/1842/16173
dc.description.abstractThis thesis sought to address the application of non-parametric item response theory (NIRT) to cognitive and functional assessment in dementia. Performance on psychometric tests is key to diagnosis and monitoring of dementia. NIRT can be used to improve the psychometric properties of tests used in dementia assessment in multiple ways: confirming an underlying unidimensional structure, establishing formal item hierarchical patterns of decline, increasing insight by examining item parameters such as difficulty and discrimination, and creating shorter tests. From a NIRT approach item difficulty refers to the ease with which an item is endorsed. Discrimination is an index of how well an item can differentiate between patients of varying levels of severity. Firstly I carried out a systematic review to identify applications of both parametric and non-parametric IRT to measures assessing global cognitive functioning in people with dementia. This review demonstrated that IRT can increase the interpretive power of cognitive assessment scales and confirmed the limited number of IRT analyses of cognitive scales in dementia populations. This thesis extended this approach by applying Mokken scaling analysis to commonly used measures of current cognitive ability (Addenbrooke’s Cognitive Examination-Revised (ACE-R)) and of premorbid cognitive ability (National Adult Reading Test (NART)). Differential item functioning (DIF) by diagnosis identified slight variations in the patterns of hierarchical decline in the ACE-R. These disease-specific sequences of decline could serve as an adjunct to diagnosis, for example where learning a name and address is a more difficult task than being orientated in time, late onset Alzheimer’s disease is a more probable diagnosis than mixed Alzheimer’s and vascular dementia. These analyses also allowed key items to be identified which can be used to create briefer scales (mini-ACE and Mini-NART) which have good psychometric properties. These scales are clinically relevant, comprising highly discriminatory, invariantly ordered items. They also allow sensitive measurement and adaptive testing and can reduce test administration time and patient stress. Impairment of functional abilities represents a crucial component of dementia diagnosis with performance on these functional tasks predictive of overall disease. A second aspect of this thesis, therefore, was the application of Mokken scaling analyses to measures of functional decline in dementia, specifically the Lawton Instrumental Activities of Daily Living (IADL) scale and Physical Self-Maintenance Scale (PSMS). While gender DIF was observed for several items, implying the likelihood of equal responses from men and women is not equal a generally consistent pattern of impairment in functional ability was observed across different types of dementia.en
dc.contributor.sponsorotheren
dc.language.isoenen
dc.publisherThe University of Edinburghen
dc.relation.hasversionHsieh, H., McGrory, S., Leslie, F., Dawson, K., Ahmed, S., Butler, C. R., ... & Hodges, J. R. (2015). The Mini-Addenbrooke's Cognitive Examination: A New Assessment Tool for Dementia. Dementia and Geriatric Cognitive Disorders, 39(1-2), 1-11.en
dc.relation.hasversionMcGrory, S., Doherty, J. M., Austin, E. J., Starr, J. M., & Shenkin, S. D. (2014). Item response theory analysis of cognitive tests in people with dementia: a systematic review. BMC Psychiatry, 14(1), 47.en
dc.relation.hasversionMcGrory, S., Starr, J.M., Shenkin, S.D., Austin, E.A. and Hodges, J.R. Does the order of item difficulty of the Addenbrooke's Cognitive Examination add anything to sub-domain scores in the clinical assessment of dementia? Dementia and Geriatric Cognitive Disorderd EXTRA, doi: 10.1159/000375364en
dc.relation.hasversionMcGrory, S., Austin, E.A., Shenkin, S.D., Starr, J.M and Deary, I.J. From ‘aisle’ to ‘labile’: a hierarchical NART scale revealed by Mokken scaling, Psychological Assessmenten
dc.relation.hasversionMcGrory, S., Shenkin, S. D., Austin, E. J., & Starr, J. M. (2014). Lawton IADL scale in dementia: can item response theory make it more informative? Age and Ageing, 43(4), 491- 495.en
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectdementiaen
dc.subjectitem response theoryen
dc.subjectMokken scalingen
dc.subjecthierarchyen
dc.titleNon-parametric item response theory applications in the assessment of dementiaen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen


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