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dc.contributor.advisorLoake, Garyen
dc.contributor.advisorOparka, Karlen
dc.contributor.authorHussain, Adilen
dc.date.accessioned2016-11-03T15:42:34Z
dc.date.available2016-11-03T15:42:34Z
dc.date.issued2013-11-28
dc.identifier.urihttp://hdl.handle.net/1842/17565
dc.description.abstractNitric oxide (NO) is a key small molecule that orchestrates plant growth, development and immune function. The chief mechanism for the transfer of NO bioactivity is thought to be S-nitrosylation, the addition of an NO moiety to a protein cysteine thiol to form an S-nitrosothiol (SNO). The enzyme S-nitrosoglutathione reductase (GSNOR) indirectly controls the total levels of cellular S-nitrosylation, by turning over S-nitrosoglutathione (GSNO), the major cellular NO donor. In tomato (Solanum lycopersicum. L) a decrease in GSNOR expression, which is expected to increase the extent of cellular SNO formation, resulted in morphological phenotypes and disabled disease resistance. In contrast, increased GSNOR activity enhanced protection against an ordinarily virulent bacterial pathogen. Collectively, these results are similar to previous findings using the reference plant, Arabidopsis thaliana. Thus, the role of GSNOR may be highly conserved across the plant kingdom and manipulating the function of this protein may control important agricultural traits in crop plants.en
dc.contributor.sponsorotheren
dc.language.isoen
dc.publisherThe University of Edinburghen
dc.relation.hasversionMalik, S.I., Hussain, A., Yun, B.W., Spoel, S.H., and Loake, G.J. (2011). GSNORmediated de-nitrosylation in the plant defence response. Plant Sci 181, 540-544.en
dc.relation.hasversionSun, X., Gilroy, E.M., Chini, A., Nurmberg, P.L., Hein, I., Lacomme, C., Birch, P.R., Hussain, A., Yun, B.W., and Loake, G.J. (2011). ADS1 encodes a MATEtransporter that negatively regulates plant disease resistance. New Phytol 192, 471-482.en
dc.subjectGSNORen
dc.subjectplant disease resistanceen
dc.subjectS-nitrosoglutathioneen
dc.titleRole of tomato S-Nitrosoglutathione Reductase (GSNOR) in plant development and disease resistanceen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen
dc.rights.embargodate2100-12-31
dcterms.accessRightsRestricted Accessen


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