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dc.contributor.advisorLam, Honen
dc.contributor.advisorHulme, Alisonen
dc.contributor.authorStephen, Jennifer Leaen
dc.date.accessioned2016-11-28T11:29:44Z
dc.date.available2016-11-28T11:29:44Z
dc.date.issued2015-11-26
dc.identifier.urihttp://hdl.handle.net/1842/18011
dc.description.abstractSome interesting, biologically active natural products have been found to contain poly-azole fragments within their core. These fragments are linked through the 2- position of one azole and the 4-position of its neighbour. Decarboxylative cross-coupling methodology may provide a route to these desired linked azoles through cross-coupling of azole-4-carboxylic acids with azole-2- halides or with azoles containing no substitution at the 2-position. Investigations into the silver-mediated decarboxylation, and subsequent coupling potential, of thiazole and oxazole-4-carboxylic acids are reported. Methods towards the synthesis of novel chlorinated thiazole and oxazole acids and their precursors are also described. A method to successfully couple these acids to aryl iodides has been developed and the scope of this reaction extended to a variety of functionalised azole-4-carboxylic acids. Attempts to extend this methodology and combine the decarboxylative coupling with CH activation of a second azole are also described.en
dc.contributor.sponsorEngineering and Physical Sciences Research Council (EPSRC)en
dc.language.isoen
dc.publisherThe University of Edinburghen
dc.subjectdecarboxylationen
dc.subjectpalladiumen
dc.subjectcross-couplingen
dc.subjectazoleen
dc.subjectCH activationen
dc.titleStudies towards the decarboxylative cross-coupling of Azole-4-carboxylic acids.en
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen
dc.rights.embargodate2100-12-31
dcterms.accessRightsRestricted Accessen


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