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dc.contributor.authorDixon, Michael F.en
dc.date.accessioned2016-12-06T10:19:30Z
dc.date.available2016-12-06T10:19:30Z
dc.date.issued1980
dc.identifier.urihttp://hdl.handle.net/1842/18147
dc.description.abstractThis thesis records my investigations into the consequences of overdosage with the analgesic drug paracetamol. The major complication, that of hepatic necrosis, has been investigated in experimental animals using light-microscopy, electron-microscopy and histo¬ chemistry. The pathological findings in 18 fatal human cases are recorded and compared and contrasted with previous reports in the literature. A further 16 fatalities resulting from overdosage with compound preparations containing paracetamol are also reported. A variety of methods for quantifying the extent of hepatic necrosis have been evaluated, including the use of the image-analysis computer, and these methods applied to experimental and human material. In addition to morphological studies, the influence of microsomal induction on the toxic meta¬ bolism of the drug has been investigated and the effectiveness of a possible antidote, a-tocopherol, has been tested in the rat. The thesis includes chapters on the history and usage of paracetamol and on the treatment of overdosage based on reviews of the literature.en
dc.publisherThe University of Edinburghen
dc.relation.ispartofAnnexe Thesis Digitisation Project 2016 Block 5en
dc.relation.isreferencedbyen
dc.titleObservations on experimental and human paracetamol overdosageen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnameMD Doctor of Medicineen


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