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dc.contributor.authorWargo, Andrew R
dc.contributor.authorde Roode, Jacobus C
dc.contributor.authorHuijben, Silvie
dc.contributor.authorDrew, Damien R
dc.contributor.authorRead, Andrew F
dc.date.accessioned2008-02-21T09:45:48Z
dc.date.available2008-02-21T09:45:48Z
dc.date.issued2007
dc.identifier.citationProc Biol Sci. 2007 October 22; 274(1625): 2629–2638.en
dc.identifier.uridoi: 10.1098/rspb.2007.0873
dc.identifier.urihttp://hdl.handle.net/1842/2141
dc.description.abstractConspecific competition occurs in a multitude of organisms, particularly in parasites, where several clones are commonly sharing limited resources inside their host. In theory, increased or decreased transmission investment might maximize parasite fitness in the face of competition, but, to our knowledge, this has not been tested experimentally. We developed and used a clone-specific, stage-specific, quantitative PCR protocol to quantify Plasmodium chabaudi replication and transmission stage densities in mixed-clone infections. We co-infected mice from two strains with an avirulent and virulent parasite clone and found competitive suppression of in-host (blood-stage) parasite densities and generally corresponding reductions in transmission stage production, with the virulent clone obtaining overall competitive superiority. In response to competitive suppression, there was little evidence of any alteration in transmission stage investment, apart from a small reduction by one of the two clones in one of the two host strains. This alteration did not result in a competitive advantage, although it might have reduced the disadvantage. This study supports much of the current literature, which predicts that conspecific in-host competition will result in a competitive advantageen
dc.format.extent212065 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherThe Royal Societyen
dc.subjectimmunology researchen
dc.titleTransmission stage investment of malaria parasites in response to in-host competitionen
dc.typeArticleen


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