Modern methods in the treatment of certain acute diseases: with special reference to (1) the specific treatment of typhoid fever; (2) the chemo-therapy of erysipelas
Recent advances in the treatment of typhoid fever and erysipelas have been made the subjects of this thesis. In the first section, an evaluation of the serum treatment of enteric fever with the new serum devised by Felix is presented, and the significance of the results obtained is discussed in detail. In the second part, an analysis of the treatment of a large series of cases of erysipelas with the recently introduced drugs belonging to the sulphanilamide group is given. Both studies, it is believed, enable certain conclusions to be drawn which are of very great practical importance.1. A series of seventy -seven cases of erysipelas treated by the sulphanilamide drugs is presented.2. An analysis of the cases in relation to the behaviour of the rash, the toxaemia, and the pyrexia, the incidence of complications and of relapse, and the fatality rate, indicates that the results obtained are significantly superior to those derived from symptomatic or serum treatment.3. So consistent are the results prevailing that sulphanilamide may be regarded as specific in erysipelas.4. Although certain toxic effects are known due to the administration of sulphmsriide, the latter is to be regarded on the whole as a safe and not unpleasant means of treatment.5. It may be that in infants the response is not so good as in older individuals, but the numbers in this series are too few to be decisive on this point.6. The exact mode of action of sulphonamide in the body is unknown. In the light of experimental knowledge and clinical observation however, a directly bactericidal action in the tissues is probably supplemented by an increased activity of the normal defence forces.