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dc.contributor.authorAlexander, Franken
dc.date.accessioned2018-01-31T11:22:42Z
dc.date.available2018-01-31T11:22:42Z
dc.date.issued1944en
dc.identifier.urihttp://hdl.handle.net/1842/26723
dc.description.abstracten
dc.description.abstractThe methods for estimating the histamine content of blood and tissue were studied and a simpler procedure adopted.en
dc.description.abstractThe histamine content of normal mice was determined and it was found that over seventy per cent of all the histamine in the body was contained in the skin.en
dc.description.abstractLarge doses of histamine were injected intravenously in mice and the clearance from the whole animal studied. The time of half clearance from the whole body was one and a half hours.en
dc.description.abstractFrom the large part of the dose present in the skin and gut immediately after injection,it appeared that histamine was rapidly taken up by the tissues.en
dc.description.abstractA part of a large dose of histamine,given to mice,was excreted in the urine, the faeces contained little more than was normally present. Excretion only took place whilst a large concentration was present in the body.en
dc.publisherThe University of Edinburghen
dc.relation.ispartofAnnexe Thesis Digitisation Project 2017 Block 15en
dc.relation.isreferencedbyAlready catalogueden
dc.title1. A study of the distribution of sulphonamides in the body; and 2. study of pharmacologically active substances present in the body by means of biological assaysen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen


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