Upon the treatment of respiratory affections: by the intra-tracheal injection of drugs
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Date
1899Author
Talent, John William
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Abstract
(1).. As the result of my observations on the above
ten patients, I conclude that the most favourable
cases for the intra-tracheal treatment, are those of
early Phthisis and Tracheitis. Holt (8) and Marland
(10) were such cases of early phthisis, and obtained
marked benefit, in fact are both returned to their
occupations in greatly improved health: the patient
Holt improved remarkably in a few days, although he
had had a cough for two years, and some loss of flesh
for two months; the slight dulness in percussion over
the apex, was however not cleared up by the treatment.
Marland felt stronger, coughed less, began to eat well and sleep well, and showed a gain in weight,, also
his sweating and diarrhoea were much lessened. These results may be taken as the usual effects of the
intra-tracheal treatment, in suitable cases. (2). In late Phthisis I found no real benefit at
all e.g., Marshall (3) and Bowden (6). Both these
were advanced cases. At first they seemed to think the
{cough was a little easier after the injection, and
that they slept better at night, but the improvement
was to me, so doubtful, that after a few trials I
gave it up (3). Phthisis which is midway between early and
date, is represented by Butler" (4): this case
took the injections steadily and easily, and improved
under them in the matter of cough, sleep and sweating though no alteration in the physical conditions
or in the temperature was observed. The reason
'of the rise of temperature in the week 83rd to
30th, is doubtful: it might be due to the injection
causing inoculation of a fresh portion of lung, a
danger which is apprehended by some. The injections
had been given daily for sixteen days before this
occurred, after that week the temperature fell, but
still remained persistently higher than before. (4). Carroll (2) Suffering from Tracheitis, represents
a class which appears likely to be very amenable to
the treatment, since here the fluids are brought
into direct contact with the inflamed surface in
a way which seems' impossible for steamed or
vapourised. medications. As a matter of fact, this
|one case was better in two days. (5). The cases I treated of Chronic Bronchitis
|were practically not improved at all. This result
|may be due to the fact that they were all three of
very old standing, and associated with emphysema,
since Dr. Thompson has got satisfactory results in
Chronic Bronchitis. Godwin (1) Mitchell (5) Wilson (9)
Godwin said that at first it eased his cough, warmed
his body and helped him to expectorate more freely:
the last injection he insisted, made him very ill,,
but this may have been an attack of dyspnoea due
to his emphysema, induced by some exertion. Wilson
and Mitchell gained no benefit whatever. As to cases of Acute Bronchitis I have had no
experience, neither of Syphilis of the lung which
Dr. Thompson says yields to this treatment, nor of
Bronchietasis as recorded by Prof. Sir.T.Grainger
Stewart In most of the patients the injections were
made without any difficulty, and without the use
of the laryngoscope. The patient holding down his
tongue, the tip of the syringe is passed downwards,
behind the "base of the tongue, the patient told
to inspire, and the injection delivered. After a few
deep inspirations and a cough or two, there was
usually no further trouble. In one or two the throat
as so sensitive as to need spraying in preparation. In McGovren's case, he was persistently sick on
taking the first meal after the injection: since
this was often in two hours' time it could hardly
be from the fluid passing down the pharynx by mis¬
take. As to the mixture injected, four different ones
have been used in the above quoted cases, viz :-
(a). Menthol 10$, Guiacol 2$, Olive Oil 88$.
This is Sir. T.Grainger.Stewart's Solution, and is
usually very soothing to"the cough and helps to sleep.
(b). Menthol 2%, Guiacol 1%, Paroleine 97%.
(c). Dr. Colin Campbell's mixture, made as follws :-
(a). Benzosol 24 grains, rectified spirit 0.5 drachm:
mix and add Price's Distilled Glycerine 0.5 ounce:
dissolve by heat. (b). Menthol 24 grains, rectified spirit drachm, glycerine (as above) 0.5 ounce:
dissolve by heat. Mix a and b and keep at a temperature of 90° Fahr. or warm before using.
(d). Thymol 5%. Guiacol 2% Paroleine 93%. This
combination, was used with good, effect.
(e). Duotal 2% Menthol 10% Paroleine 88%. This
I have had made up but have not yet used.
Prof. Bayer of Brussels has lately used warmed
creosotal in cases of tuberculosis and chronic
bronchial catarrhs, injecting to 0.5 to 1.5 cub. cms. every
second day.