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dc.contributor.authorBradley, Ronald James.en
dc.date.accessioned2018-01-31T11:34:10Z
dc.date.available2018-01-31T11:34:10Z
dc.date.issued1967
dc.identifier.urihttp://hdl.handle.net/1842/27135
dc.description.abstracten
dc.description.abstractThis thesis has placed especial emphasis upon the nature of IRT generation within a DRLLH schedule. Perhaps an interested reader may turn to the serial probabilities listed in the Computer Appendices and uncover relationships which were left undetected by the present author. The use of the high speed digital computer in the analysis of IRT data should open up a whole new vista for the experimental analysis of behaviour. Unfortunately, as with all sophisticated equipment, the computer is a perpetual source of reinforcement and psychology will have to contend with yet another revolution. The computer revolution may be typified by the nonchalant application of wasteful and inappropriate mathematical techniques worked out at great speed and expense and with an appropriate lack of experimenter participation. However, simple probability calculations derived from serial IRT data should provide a host of new experimental ideas and explanations for the behavioural scientist.en
dc.description.abstractAt present, the use of operant techniques in pharmacological research is accelerating and may herald one of the most rewarding areas for interdisciplinary research. There is unfortunately no such thing as interdisciplinary science, there are only interdisciplinary scientists. It is pure fiction to imagine groups of of psychologists, pharmacologists, biochemists, physicists, mathematicians and clinicians all working productively and in perfect - harmony.en
dc.description.abstractIt is necessary to have an interdisciplinary mind in order to pose a meaningful interdisciplinary question and the formulation of that question is such, that only a scientist of wide experience can understand the terms of reference and in turn question the primary assumptions. This situation illustrates a peculiar virtue of interdisciplinary study in that a practitioner in one scientific discipline may be, through his inability to comprehend the traditions and approaches of another science, able to question its basic postulates and reformulate its problems in a new and useful way. As yet, psychologists have not made such a contribution to pharmacology.en
dc.description.abstractRecent developments in psychopharmacology have favoured the appearance of so- called pretreatment experiments. That is, the modification of drug effects by prior treatment with other pharmacological agents. The most popular pretreatment compounds have been the MAOIs and on the basis of the pretreatment effect it is possible to hypothesise as to the nature of the pharmacological activity of the compound under investigation. A great deal of spurious theory and subsequent sterility of experimentation has arisen from the fact that some behavioural pharmacologists understand little about MAO and even less about drug receptor interaction. MAO was discovered in 1928 and still, the best preparation of the enzyme are impure and we know nothing of its kinetics or cofactor. It may even be a combination of many enzymes, but all we know is that the oxidation can be inhibited by certain compounds (MAOIs). As regards the receptor site, Paton (1967) has reviewed the relevant literature and concludes,en
dc.description.abstract"This situation has made me become increasingly dubious whether we can with confidence make answers even to the simplest questions about the interaction of sympathetic amines with their receptors ".en
dc.description.abstractThe pharmacologist may turn to a physiologist for advice about the stability and sensitivity of his rat fundus strip, or other bioassay preparation. It is the function of the behavioural scientist to ensure that the pharmacologist can turn to him for information about behavioural baselines.en
dc.publisherThe University of Edinburghen
dc.relation.ispartofAnnexe Thesis Digitisation Project 2017 Block 16en
dc.relation.isreferencedbyen
dc.titleSome properties of behavioural baselines in the rat and disruption by the psychotomimetic drugsen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelen
dc.type.qualificationnamePhD Doctor of Philosophyen


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