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dc.contributor.authorRitchie, David.en
dc.date.accessioned2018-01-31T11:36:00Z
dc.date.available2018-01-31T11:36:00Z
dc.date.issued1950
dc.identifier.urihttp://hdl.handle.net/1842/27274
dc.description.abstracten
dc.description.abstract(1) From p-alkoxy and m-p-dialkoxy benzylidene acetones, utilising the Mannich reaction, a series of unsaturated alkyl amino ketones of the type (I)en
dc.description.abstracthas been prepared as hydrochlorides and the pyrazolines derived therefrom (II) have been synthesised and isolated as hydrochlorides or tartrates:en
dc.description.abstract(2) The new pyrazolines have been found to be potent local anaesthetics for topical and intradermal use.en
dc.description.abstract(3) In examining the topical activities on the cornea of guinea -pigs it was found that the effect of the size of the amino substituents on the ß-carbon atom of the 3 -ethyl group (i.e. the group NR") varieden
dc.description.abstractThe regression lines of the logarithms of the concentration against duration of topical anaesthesia have been found to be parallel in the case of all the pyrazolines and nupercaine. This last drug was therefore chosen as a suitable reference standard of activity. Cocaine, it was found however, could not be used for this purpose on account of the fact that the slope of the regression line in this case differ - :ed from that of the other drugs. This may be due to the fact that cocaine has a pronounced vaso- :constrictor activity.en
dc.description.abstract(4) The effect of change in size of the alkoxy groups substituted in the 5- phenyl nucleus on the topical activity has not been so fully examined, but it appears that the p -n- propoxy derivatives are the most activeen
dc.description.abstract(5) The effect of changes in the size of the amino substituents of the ß-carbon in the 3-ethyl group on the intradermal activity of the drugs synthesiseden
dc.description.abstract(6) The effect of the alkoxy substituents (R.O. and R'.0) upon the toxicity indicates that there is a slight decrease in toxicity with increase in size and number of alkoxy substituentsen
dc.description.abstract(7) The effect of the amino substituents (N.R") upon toxicity has not been fully examined but the diethylamino compound is more toxic than the piperidino compound where the substituent in the 5-position is 3-methoxy-4-n-propoxy-phenyl.en
dc.publisherThe University of Edinburghen
dc.relation.ispartofAnnexe Thesis Digitisation Project 2017 Block 16en
dc.relation.isreferencedbyen
dc.titleSynthesis of pyrazoline derivatives and an examination of their local anaesthetic activityen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelen
dc.type.qualificationnamePhD Doctor of Philosophyen


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