In 1933, Cecily Williams]. described a deficiency syndrome found in children on the West Coast of Africa. This syndrome, which was characterized by oedema, diffuse depigmentation and desquamation, angular stomatitis, eheilosis, glossitis, pale and atrophic hair and a grossly fatty liver was subsequently named KWASHIORKOR or 'Red Boy! Stannus3 in 1934 expressed the belief that this disease was Pellagra as it appeared in children in warm climates.
In 1937 a comprehensive account of the syndrome was published by Trowell who, at that time, accepted it as that of infantile pellagra. Later, (1944) he stated that he could no longer consider the condition to be that of pellagra and suggested the term "MALIGNANT MALNUTRITION" for the disease.
Since Kwashiorkor was first described a voluminous literature on the subject has appeared and cases have been reported from many parts of Africa, South and Central America, China and India.
One of the features of this condition was the high mortality rate associated with it, even when skilled treatment was available. Hughes 1946:, for example, reported deaths over three years as follows: - 1942/3, 58%; 1944, 58 %; 1945, 50%; but more recently Altman has reported a mortality of 20% and Trowell one of less than 10%.
The purpose of this Thesis is to record cases of Malignant Malnutrition seen in Luanshya, Northern Rhodesia and to discuss the aetiology, clinical manifestations, pathology and treatment of this condition.