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Remote, non-invasive ischaemic preconditioning of skeletal muscle flaps against ischaemic necrosis : efficacy and mechanism

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AddisonP_2006redux.pdf (20.20Mb)
Date
2006
Author
Addison, Patrick
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Abstract
 
 
HYPOTHESIS: That skeletal muscle, throughout the body, can be preconditioned to better withstand prolonged periods of ischaemia, by first subjecting a remote muscle to brief, non-invasive and sub-lethal, cycles of ischaemia and reperfusion, using a hindlimb tourniquet.
 
AIMS: The aims of the project were:
 
1) To test the hypothesis, using porcine Latissimus Dorsi, Rectus Abdominis and Gracilis muscle flaps.
 
2) To define the potency and time course of the protective effect of remote ischaemic preconditioning in this model.
 
3) To assess the physiological effects of remote ischaemic preconditioning both in terms of energy metabolism during subsequent prolonged ischaemia, and postischaemic blood flow
 
4) To investigate the mechanism of remote ischaemic preconditioning in this model.
 
URI
http://hdl.handle.net/1842/27899
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  • Edinburgh Medical School thesis and dissertation collection

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