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dc.contributor.authorEarle, Frances Margareten
dc.date.accessioned2018-01-31T11:43:07Z
dc.date.available2018-01-31T11:43:07Z
dc.date.issued1950en
dc.identifier.urihttp://hdl.handle.net/1842/27968
dc.description.abstracten
dc.description.abstractIn this investigation, a study has been made of variations in gastric function occurring in four common pathological conditions of infancy.en
dc.description.abstractGruel was chosen as the material for the test meal for several reasons. It can be given to any child without causing alimentary upset, and it is easily aspirated through a narrow bore tube. The motor function óf the stomach can be studied by the presence or absence of starch in the fractional specimens. Gruel stimulates gastric secretion satisfactorily, and does not bind much free hydrochloric acid; this low buffering power is important, and is associated with a negligible incidence of achlorhydria in healthy children.en
dc.description.abstractIn children, as in adults, histamine is used to differentiate between true and false achlorhydria. Comfort and Osterberg showed that histamine does not always evoke a full response from the acid- secreting cells of the gastric mucosa, and the consistency of the response can be questioned; they noted one case in their series in which an Ewald test meal evoked a free acid secretion, whereas histamine did not; in two other cases, the response from histamine stimulation was smaller than from an Ewald test meal; Gaither agreed with this. On the other hand, Bockhus, Bank and Willard (9) considered that if large enough doses of histamine were given, (sufficient to produce cutaneous erythema), one never failed to get hydrochloric acid formation, if the mucosa was capable of producing it.en
dc.description.abstractIn view of the work of Comfort and Osterberg (16) and of Gaither (36), it was decided to combine gruel with histamine as a test meal stimulus, if it was desired to repeat the gastric investigation of infants showing achlorhydria. The dose of histamine chosen (0.02 mgm. per kilo) was found by Cutter (21) invariably to produce cutaneous erythema in infants. It was realised that there would be some dilution of the gastric contents by the gruel, and perhaps some neutralization of the hydrochloric acid secreted. Any neutralization, however, would be reflected in an increase of the combined and total acidity compared with the first examination, and could be judged accordingly.en
dc.description.abstractThe results of the present work, showed that in normal infants, gastric acidity increased during the first year of life. Secretion was low at 3 to L weeks, there was a rapid rise in the 1 to 3 month age period, and a much slower rise thereafter. The combined acidity was high in the 1 to 3 month age period, but there was a tendency for it to decrease in the second 6 months of life. Cutter's investigation (21) with histamine showed a similar trend, though the free and total acidity reached much higher figures by 1 year of age.en
dc.publisherThe University of Edinburghen
dc.relation.ispartofAnnexe Thesis Digitisation Project 2017 Block 16en
dc.relation.isreferencedbyen
dc.titleA study of the gastric secretion of healthy and ill infants in the first year of lifeen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelen
dc.type.qualificationnamePhD Doctor of Philosophyen


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