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dc.contributor.authorJeans, Lindsay Annen
dc.date.accessioned2018-03-29T12:17:30Z
dc.date.available2018-03-29T12:17:30Z
dc.date.issued2006
dc.identifier.urihttp://hdl.handle.net/1842/29180
dc.description.abstracten
dc.description.abstractThe experiments presented in this thesis are a study in which the use of a biodegradable glass wrap was compared with microsurgical epineurial suturing as a means of repairing cleanly divided median nerves in a sheep model.en
dc.description.abstractTwelve sheep were used in a control group and in each of four repair groups in which the following procedures were carried out:en
dc.description.abstract1. Neurotmesis and repair using microsurgically placed epineurial sutures of 10/0 polyamideen
dc.description.abstract2. Neurotmesis and repair by entubulation with the biodegradable glass wrap secured by 6/0 polyglactin macrosuturesen
dc.description.abstract3. Neurotmesis and repair by entubulation with the biodegradable glass wrap secured by fibrin (Tisseel) glueen
dc.description.abstract4. Neurotmesis and repair by entubulation with the biodegradable glass wrap secured with polycaprolactone glue.en
dc.description.abstractNo gap was left between the proximal and distal stumps. Electrophysiological tests on the median nerve, flexor carpi radialis muscle and flexor digitorum superficialis muscle were carried out seven months after the repair and a portion of the median nerve distal to the repair site was excised for morphometric examination after all electrophysiological testing had been completed.en
dc.description.abstractThe main conclusions of the present study were:en
dc.description.abstract1. Nerves repaired with the biodegradable glass wrap and fibrin glue displayed distal neuronal regeneration that was no different from that which occurred after a tensionless microsurgical epineurial suture. This biodegradable glass wrap, secured with fibrin (Tisseel) glue, could therefore be used in humans to repair simple nerve divisions.en
dc.description.abstract2. Using the wrap in nerve repair is simple and is quicker and less expensive than microsurgical epineurial suture.en
dc.description.abstract3. Nerve regeneration after nerve repair could be assessed in humans by measuring maximum conduction velocity (CVmax) (m s⁻¹) and transcutaneous stimulated jitter (TSJ) (μs)en
dc.publisherThe University of Edinburghen
dc.relation.ispartofAnnexe Thesis Digitisation Project 2018 Block 17en
dc.relation.isreferencedbyAlready catalogueden
dc.titleEvaluation of a simplified technique for nerve repair by means of entubulation by flexible controlled release glassen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnameMD Doctor of Medicineen


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