Abstract
A method is described for the separation of
organic poisons - alkaloids, other bases, glucosides
and barbiturates. It depends on extraction of the
poison and removal of fats and proteins by trichloracetic acid; adsorption of the bases on Novasorb
or kaolin and of the non -basic substances on charcoal; and extraction from the adsorbent by
chloroform, ether, etc. under suitable conditions.
Evidence is advanced to show that removal of
the poison at each stage is complete.
Figures are given for the percentage recovery
of various poisons (a) when added to meat, (b) when
the poison has been injected into an animal.
Results by the new method are compared with
those by the standard Stas -Otto process. It is
shown that the new method (a) gives better percentage
recovery in most cases, (b) represents a very
considerable saving of time and labour, (c) yields
a purer product from the solution in immiscible
solvent.
Experiments are described to show the limits of
sensitivity of the extraction process, its use in
separating two organic poisons present together, etc.
The method can be applied for extraction of
alkaloids from natural sources.
