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An improved method of extracting organic poisons for use in toxicological analysis

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ChatterjiSK_1938redux.pdf (9.179Mb)
Date
1938
Author
Chatterji, S. K.
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Abstract
 
 
A method is described for the separation of organic poisons - alkaloids, other bases, glucosides and barbiturates. It depends on extraction of the poison and removal of fats and proteins by trichloracetic acid; adsorption of the bases on Novasorb or kaolin and of the non -basic substances on charcoal; and extraction from the adsorbent by chloroform, ether, etc. under suitable conditions.
 
Evidence is advanced to show that removal of the poison at each stage is complete.
 
Figures are given for the percentage recovery of various poisons (a) when added to meat, (b) when the poison has been injected into an animal.
 
Results by the new method are compared with those by the standard Stas -Otto process. It is shown that the new method (a) gives better percentage recovery in most cases, (b) represents a very considerable saving of time and labour, (c) yields a purer product from the solution in immiscible solvent.
 
Experiments are described to show the limits of sensitivity of the extraction process, its use in separating two organic poisons present together, etc.
 
The method can be applied for extraction of alkaloids from natural sources.
 
URI
http://hdl.handle.net/1842/29653
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