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dc.contributor.authorKanui, Titus Ikusyaen
dc.date.accessioned2018-05-14T10:13:45Z
dc.date.available2018-05-14T10:13:45Z
dc.date.issued1983
dc.identifier.urihttp://hdl.handle.net/1842/29827
dc.description.abstracten
dc.description.abstract1 . The aim of this study was to investigate the neurophysiological basis for thermal analgesia. The speculation that part of this analgesia may be mediated via depression of nociceptor driven spinal cord tract neurones was tested.en
dc.description.abstractSpinal segments L6 to S1 were explored with extracellular mi'cropipette electrodes filled with a mixture of 5M sodium chloride and pontamine sky blue (2% in 0.5 M sodium acetate) in rats anaesthetised with chloralose (100 mg kg⁻¹) and urethane (700 mg kg⁻¹).en
dc.description.abstract3. 258 neurones were recorded from within the dorsal horn and were tested for the inhibitory effect of thermal stimulation applied to the perineal, inguinal and scrotal skin. Ten of the 258 units received only a warm inhibitory input from the skin. 57 units had an excitatory input from nociceptors, of these 24 were inhibited by warming and 2 by cooling the skin.en
dc.description.abstract4. Data has also teen obtained on the light microscopic anatomy of the scrotal skin and also on 73 units that had an input from thermoreceptors.en
dc.description.abstract5. It is suggested that thermal inhibition of units that have an input from nociceptors may provide some neurophysiological basis for thermal analgesia.en
dc.publisherThe University of Edinburghen
dc.relation.ispartofAnnexe Thesis Digitisation Project 2018 Block 18en
dc.relation.isreferencedbyAlready catalogueden
dc.titleElectrophysiological study of spinal cord thermoreceptive neurones in the raten
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen


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