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dc.contributor.authorRae, Alistair Gordon.en
dc.date.accessioned2018-05-14T10:15:35Z
dc.date.available2018-05-14T10:15:35Z
dc.date.issued1985en
dc.identifier.urihttp://hdl.handle.net/1842/29958
dc.description.abstracten
dc.description.abstractThe role of mycoplasmas, especially ureaplasmas, in the urogenital tract of sheep was investigated both by survey and by pathogenicity experiments in vitro and in vivo.en
dc.description.abstractThe survey revealed that Ureaplasma are the most frequently isolated species from the ovine urogenital tract, and demonstrated an association between the occurrence of vulvovaginitis and the presence of ureaplasmas. M.capricolum and A.axanthum, two species not previously reported in the United Kingdom, were among the other seven species isolated.en
dc.description.abstractDifferences in virulence of the strains of ureaplasma isolated from sheep were investigated using both in vitro and in vivo systems. The in vitro systems used were cell and organ cultures as well as embryonated hens' eggs, but although none of these gave successful results, a cytopathic effect observed in ovine uterus cell cultures did suggest that these organisms are potentially pathogenic. The various in vivo systems investigated included inoculation of several animal species by a variety of routes. The production of mastitis in lactating mice after intramammary inoculation confirmed the pathogenicity seen in cell cultures but possible variations in virulence between strains were not identified by this model. However, the strains varied in their ability to induce mastitis in the lactating bovine udder, suggesting that variations in virulence do occur but are revealed only by in vivo systems.en
dc.description.abstractTransmission experiments in sheep were carried out and demonstrated that inoculation of these organisms per vaginam resulted in vulvitis. They showed also the importance of venereal transmission in the spread of the organisms to previously unmated ewes, some of which developed vulvitis. Ureaplasmas could be consistently recovered from all animals which developed the disease. The vulvitis did not affect conception rates or the reproductive efficiency of the ewes.en
dc.description.abstractTwo serological tests (metabolism-inhibition and indirect immunofluorescence) demonstrated that at least three groups of ovine ureaplasmas occur in the United Kingdom. All 106 strains examined in this study could be assigned to one of the three groups, using antisera prepared in specific pathogen-free lambs ,against a representative of each group.en
dc.publisherThe University of Edinburghen
dc.relation.ispartofAnnexe Thesis Digitisation Project 2018 Block 18en
dc.relation.isreferencedbyAlready catalogueden
dc.titleMycoplasmas of the urogenital tract of sheepen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen


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