The euglobulin lysis time before and after moderate exercise and before
and after intravenous adrenaline has been studied in normal subjects between
the ages 18 -30 years. The resting euglobulin lysis time varied from subject to
subject and from day to day in the same subject. There was a highly significant
lower level in the females. There was no correlation in the resting levels
of euglobulin lysis time with the menstrual cycle.
The fibrinolytic reactivity to moderate exercise and intravenous adrenaline
was reproducible in anyone individual, but there was significant difference
in reactivity between individuals, which revealed the presence of a group of
consistently poor reactors. The fibrinolytic reactivity in women, of the same
age group, was significantly greater than men, but there appeared to be no
changes coincident with the phases of the menstrual cycle.
The possible significance of these findings are discussed in the light of
Astrup's hypothesis of the aetiology of atherosclerosis and /or thrombosis.