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dc.contributor.authorWhitaker, Donald Callumen
dc.date.accessioned2018-05-22T12:49:55Z
dc.date.available2018-05-22T12:49:55Z
dc.date.issued2006
dc.identifier.urihttp://hdl.handle.net/1842/30916
dc.description.abstracten
dc.description.abstractOBJECTIVE: A randomised clinical trial sought evidence as to whether leucocyte depleting arterial line filters had any effect on intra- operative cerebral microemboli and post- operative neuropsychological outcome in non emergency patients undergoing coronary artery bypass (CABG) surgery.en
dc.description.abstractMETHODS: One hundred and ninety -two patients were randomised to the use of a Pall LG -6 leucocyte depleting (test) filter or either an Avecor Affinity or Pall AV -6 control filter. Cerebral microemboli during surgery were recorded by transcranial Doppler monitor over the right middle cerebral artery. Evidence of cerebral impairment was obtained by comparing patients' performance in a neuropsychological test battery (9 tests) administered 6 -8 weeks post-operatively with their pre-operative scores.en
dc.description.abstractRESULTS: The groups proved well balanced in pre- operative variables. During cardiopulmonary bypass the median number and range of microemboli was 15 (3 -180) in the leucocyte depleting group compared to 67 (5 -846) and 55 (2 -773) for the Avecor and AV6 groups respectively (p <0.0001). One hundred and sixty -one patients completed all the neuropsychological tests. The leucocyte depleting group showed better post- operative performance in all but one of the nine tests although the difference in a total change score did not reach significance (p = 0.07, 1 tailed t test).en
dc.description.abstractCONCLUSION: Leucocyte depleting filtration during CABG reduced the number of cerebral microemboli recorded by transcranial Doppler and showed a strong trend towards improving neuropsychological performance post -operatively. These findings suggest that the use of such filters in CABG surgery may offer increased neuroprotection.en
dc.publisherThe University of Edinburghen
dc.relation.ispartofAnnexe Thesis Digitisation Project 2018 Block 19en
dc.relation.isreferencedbyAlready catalogueden
dc.titleA clinical study of the effect of leucocyte depleting arterial line filtration on cerebral microemboli and neuropsychological outcome after coronary artery bypass surgeryen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnameMD Doctor of Medicineen


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