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dc.contributor.advisorThomas, Stephen
dc.contributor.advisorSchneider, Uwe
dc.contributor.authorPaliga, James Francis
dc.date.accessioned2018-06-11T09:38:45Z
dc.date.available2018-06-11T09:38:45Z
dc.date.issued2018-07-09
dc.identifier.urihttp://hdl.handle.net/1842/31115
dc.description.abstractThe iron-catalysed hydromagnesiation of styrene derivatives has been developed further from previous publications, expanding the electrophile scope to enable the regioselective formation of new carbon-carbon and carbon-heteroatom bonds (Scheme A1). A commercially available pre-catalyst and ligand were used to give an operationally simple procedure that did not require prior synthesis of a catalyst. This work also investigated the hydromagnesiation of dienes, using a screen of ligands commonly used in transition metal catalysis. An investigation into the magnesium-catalysed hydroboration of olefins was also carried out. Although mostly unsuccessful, it was demonstrated that in the presence of a magnesium catalyst, a small amount of vinyl boronic ester could be formed from an alkyne (Scheme A2). Simple magnesium salts were also investigated for the reduction of carbonyls. Lastly, this work explored the titanium-catalysed hydrosilylation of olefins, using a novel activation method developed within the group (Scheme A3). The results were compared to those published previously using traditional organometallic activation methods and attempts at identifying conditions to improve chemoselectivity were carried out.en
dc.contributor.sponsorEngineering and Physical Sciences Research Council (EPSRC)en
dc.language.isoenen
dc.publisherThe University of Edinburghen
dc.relation.hasversionJones, A. S.; Paliga, J. F., Greenhalgh, M. D.; Quibell, J. M.; Steven, A.; Thomas, S. P. Org. Lett. 2014, 16, 5964-5967.en
dc.subjectcatalysisen
dc.subjectnovel reactionsen
dc.subjectiron catalysten
dc.subjectmagnesiumen
dc.subjecttitanium-catalysed reactionen
dc.titleDeveloping Earth-abundant metal-catalysts for hydrofunctionalisationen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen
dc.rights.embargodate2019-07-09en
dcterms.accessRightsRestricted Accessen


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