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dc.contributor.authorDoyle, Daviden
dc.date.accessioned2018-09-13T15:48:07Z
dc.date.available2018-09-13T15:48:07Z
dc.date.issued1967
dc.identifier.urihttp://hdl.handle.net/1842/31825
dc.description.abstracten
dc.description.abstractA number of changes have been shown to occur in an orderly sequence after porto-caval anastomosis (Fig. 75).en
dc.description.abstractA strikingchange occurs in body weight. This falls during the first 20 - 30 days after anastomosis. If the animal survive a further period of 20 - 30 days of weight stability ensue, and thereafter there is a tendency for body weight to recover. The constancy of this pattern of behaviour suggests that the three phases could be labelled decompensation, balance and recovery.en
dc.description.abstractDuring the phase of decompensation the liver weight drops to approximately 40% of the exprted value and remains at the new proportion to body weight in spite of the phase of recovery. Plasma ammonium concentration is elevated after shunting, but the level does not increase with time.en
dc.description.abstractDuring the phases of decompensation and stability, no changes in the nervous system have been detected. After 55 days, morphological changes in astrocytes occur, and the changes appear to become more prominent with the progression of time (Figs.76 & VT). These morphological changes are identical with the astrocytic changes seen in some forms of liver disease and in 'Qiilson's disease.en
dc.description.abstractThroughout the course of the animal 'S ppost operative life there is an increased rate of DNA synthesis by, and division of renal tubular cells, without significant accretion of kidney mass. The rate of turnover of tubular cells probably increases as time proceeds after anastomosis.en
dc.description.abstractThroughout the course of the animal's post- operativeTLfe, but particularly in the first 50 days, there is a liability to haemorrhage from gastric erosions. No chronic gastric mucosal lesions have been demonstrated.en
dc.description.abstractNo evidence for the implication of cerebral monoamine oxidase in the pathogenesis of hepatic encephalopathy was sustained. The splenic mass is reduced after porto-caval anastomosis.en
dc.description.abstractThe splenic mass is reduced after porto -caval anastomosis.en
dc.publisherThe University of Edinburghen
dc.relation.ispartofAnnexe Thesis Digitisation Project 2018 Block 20en
dc.relation.isreferencedbyen
dc.titlePorto-caval anastomosis in ratsen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnameMD Doctor of Medicineen


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