While I was resident physician in the wards of the
Royal Infirmary, Edinburgh, Dr. Chalmers Watson suggested I should study the injection of iodine intravenously. I chose
twelve cases at random, and the following is an account of the
preparation used; the technique; and the results.
The preparation used consisted of:-
Iodine i drachm; Potassium Iodide 1 drachm; Distilled Water 5 ounces;
Minims 20 of the above in 10 cc. Normal Saline was
the quantity used for each injection, i.e. gr. 0.5 of Iodine.
The injection was given intravenously at 11 A.M.
For some days prior to the injection all patients
were placed on a uniform diet, etc. with a view to eliminating
as far as possible any error arising from altered environment.
Each experiment lasted three days.
Observations were made on temperature, respiration
rate, pulse rate, systolic and diastolic pressure; urine per
hour (quantity, specific gravity, urea concentration, and
abnormal constituents); influence on the leucocyte count; anti
the Basal Metabolic Rate ( B.M.R.)
Careful observations were taken at frequent intervals
throughout each day, noting the patients general condition,
size of thyroid, and any variations in the symptomatology,
both subjective and objective.
On the first day control observations were made. On
the second day Iodine was administered intravenously at
11 A.M., and the results carefully studied; while on the
third day observations were made on similar lines. For the
following few days the patients" condition was carefully