Study of viruses isolated in the tropics

Abstract

This thesis is based on studies of the properties and epidemiology of viruses isolated in Africa. Investigations of the epidemiology of yellow fever and of new methods of vaccinating against it are described in the first series of papers. These yellow fever studies led incidentally to the recovery of several previously unknown viruses. Two of these which were called Zika virus and Uganda S virus are described in the second group of publications; the epidemiology of a number of recently discovered African viruses including Mengo encephalomyelitis virus is then discussed. The next series of papers describe the relationship of Mengo encephalomyelitis virus to poliomyelitis virus and an extension of these investigations which led to studies of poliomyelitis in Central Africa and of methods of preparing vaccines to prevent it. In conclusion reference is made to some current work which may lead to an understanding of some of the problems raised in the studies of the African viruses.

The papers submitted are a selection of work published in the course of the above investigations.

List of Included Supporting Publications: 01. Yellow Fever - A Problem in Epidemiology || 02. The Neutralization of French Neurotropic Yellow Fever virus by Sera of Bwamba Children || 03. Monkeys in Relation to the Epidemiology of Yellow Fever in Uganda || 04. Further Studies on the Susceptibility of African Wild Animals to Yellow Fever || 05. Immunity to Yellow Fever Nine Years after Vaccination with 17D Vaccine || 06. A Preliminary Evaluation of the Immunizing Power of Chick -Embryo 17D Yellow Fever Vaccine Inoculated by Scarification || 07. Vaccination by Scarification with a combined 17D Yellow Fever and Vaccinia Vaccine || 08. Uganda S Virus || 09. Zika Virus || 10. Zika Virus. (II). Pathogenicity and Physical Properties || 11. Epidemiological Notes on some Viruses Isolated in Uganda || 12. The Relationship of Mengo Encephalomyelitis, Encephalomyocarditis, Columbia -SK and M.M. Viruses || 13. A Study of the Presence of Poliomyelitis among Isolated Communities in Central Africa || 14. The Similarity of Brazzaville Encephalomyelitis Virus and Type I Poliomyelitis Virus || 15. Persistence of Brunhilde Poliomyelitis Virus in Rodent Brain without Evidence of Adaptation || 16. Immunization of Cotton Rats with Inactivated Lansing Poliomyelitis Virus. I. Inactivation by Chemical Agents || 17. Immunization of Cotton Rats with Inactivated Lansing Poliomyelitis Virus. II. Inactivation by Physical Methods || 18. Note on Current Research