As to the relationship of the
Suprarenal cortex to the production of Exophthalmic
Our study of the literature, and of the pathological,
clinical and experimental evidence leads us to
1. That Marine does not show sufficient proof
to render his theory tenable.
His results have not been repeated by
Swingle and Pfiffner's work has been in
contradistinction to that of Marine.
We must conclude that the effect of the
suprarenal cortex is to raise Basal
Metabolicm, rather than to lower it.
2. That pathological findings do not support
the view that defect of the suprarenal
cortex leads to hyperthyroidism.
3. That the results of treatment of hyperthyroidism
by means of cortical extract are
4. That the suprarenal cortex and the thymus
have some synergistic inter- action, and
there is some evidence to show that the
thymus is antagonistic to the thyroid.
As, however, the inter -relationship of the
Endocrine organs is so complicated, and as
yet much of their relationship is obscure,
we cannot consider this fact of sufficient
weight to all:w us to draw any conclusion
as to the antagonism of the suprarenal
cortex and the thyroid.
5. Our conclusions as to the function of the
thyroid do not give us any indication of
antagonism between the thyroid and the
suprarenal cortex. While, therefore, it
is possible that the future may show us that
the suprarenal cortex is involved in the production
of hyperthyroidism in some indirect measure, yet at
present we can only conclude that the evidence which
we at present have, is against any direct action of
the suprarenal cortex in the production of