#1. The observations on which this thesis is based
were made by me in the course of routine duties
as an assistant in general practice.
#2. A description of the type of practice is given
and of the method of selection of cases for
#3. The desirability of performing blood counts as a
routine diagnostic measure in general practice is
#4. The normal figures for haemoglobin and red blood
corpuscles are stated.
#5. The various methods by which the percentage of
circulating haemoglöbin in healthy blood is
calculated, are described in some detail.
#6. The Haldane scale is defined.
#7. The necessity for standardisation of all
haemoglobinometers in terms of absolute values
#8. The reasons for rejecting the uncorrected figures
given by my Sahli Haemoglobinometer are stated.
#9. The standardisation of my Haemoglobinometer is
#10. The phenomenon of the increasing depth of colour
in a newly prepared sßlution of acid haematin
#11. Figures obtained from an investigation of this
phenomenon are used to establish a method for the
quick conversion of readings on the Sahli
Haemoglobinometer into percentages on the Haldane
#12. The principle of the diffraction method of measur
:ing the mean red cell diameter is described and
its limitations outlined.
#13. My experience with an instrument of this type
#14. The case notes of 86 patients observed over a
period of 1* years in general practice, are given
together with the blood picture, treatment, and
#15. Three cases of pernicious anaemia observed in
hospital are added.
#16. The clinical classification of 68 cases of anaemi
in general practice is given. The cases fall int
the following groups, according to age:
1. Children 14 cases;
2. Adolescents 1 case;
3. Adult males 7 cases;
4. Adult females 46 cases.
The cliñical subdivision of these groups reveal
Hypochromic anaemia in children 14 cases;
Hypochromic anaemia in adolescents., 1 case;
Pernicious anaemia 4 case;:
Hypochromic anaemia in adult males 5 case;;
Hypochromic anaemia in females 44 cases;
#17. When cases of pernicious anaemia and cases with
a demonstrable organic basis are excluded, only
33 cases of idiopathic hypochromic anaemia
remain. Of these 30 occurred in adult females,
and 3 in children.
#18. It is therefore concluded that an idiopathic
hypochromic anaemia in which no underlying
pathology is found is common only in children
#19. 26 of the cases of idiopathic anaemia in adult
females are discussed as a whole.
#20. The importance of dietary deficiency and iron los
due to menstruation are stressed.
#21. The high incidence of the condition in the re-
productive period, and especially towards the
menopause is stressed.
#22. The role of repeated pregnancies in the aetiology
of hypochromic anaemia is minimised.
#23. The symptomatology is discussed and the incidence
of glossitis, dysphagia, koilonychia, dyspepsia,
amenorrhoea, and menorrhagia are noted:
1. In relation to the total number of cases (26);
2. In relation to the degree of anaemia present.
#24. The response to treatment is indicated.
#25. The other hypochromic anaemias found in adult
females are very briefly noted under appropriate
#26. Seven cases of pernicious anaemia are discussed.
#27. Two cases of hyperpoiesis associated with
pernicious anaemia are described.
#28. The financial aspect of pernicious anaemia is
stressed, and the average weekly cost of
maintenance of the seven cases are noted in
#29. It is shown that parenteral injection is a
cheaper method of therapy than the exhibition of
raw liver orally.
#30. It is suggested that Anahaemin is a cheaper and
more efficient liver extract than Campolon.
#31. cases of hypochromic anaemia occurring in
adult males are briefly noted under appropriate
#32. Fourteen cases of hypochromic anaemia in children
are discussed as a whole. The associated
pathological lesions are noted.
#33. The importance of thorough examination of anaemic
children in order to discover the underlying
pathology, is illustrated.