Biological Sciences publications
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Recent Submissions
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Taxonomic study of the genus Xanthomonas
(The University of Edinburgh, 1958) -
Molecular structure of plant gums with special reference to gum tragacanth and gums of the sterculia genus
(The University of Edinburgh, 1964) -
qpMerge: Merging different peptide isoforms using a motif centric strategy
(biorxiv, 2016)Accurate quantification and enumeration of peptide motifs is hampered by redundancy in peptide identification. A single phosphorylation motif may be split across charge states, alternative modifications (e.g. acetylation ... -
Practical evaluation of SEEK and OpenBIS for biological data management in SynthSys; second report.
(SBS, University of Edinburgh, 2016-03-11)The objective of this joint project between University Information Services (IS) and the School of Biological Sciences (SBS) is to evaluate the provision of Biological Data Management systems and their integration with ... -
Changing planetary rotation rescues the biological clock mutant lhy cca1 of Arabidopsis thaliana
(bioRxiv at Cold Spring Harbor Laboratory, 2015-12-17)Background: Pervasive, 24-hour rhythms from the biological clock affect diverse biological processes in metabolism and behaviour, including the human cell division cycle and sleep-wake cycle, nightly transpiration and ... -
Practical evaluation of SEEK and OpenBIS for biological data management in SynthSys; first report
(2015-10-30)The project evaluated two existing data management systems for a small set of users, who represent diverse needs within the SynthSys Centre, in order to inform wider adoption for biological research. SEEK’s strengths are ... -
Low-temperature-specific effects of PHYTOCHROME C on the circadian clock in Arabidopsis suggest that PHYC underlies natural variation in biological timing
(bioRxiv, at Cold Spring Harbor Laboratory, 2015-11-04)The circadian clock is a fundamental feature of gene regulation and cell physiology in eukaryotes and some prokaryotes, and an exemplar gene regulatory network in Systems Biology. The circadian system in Arabidopsis thaliana ... -
Construction of a large scale integrated map of macrophage pathogen recognition and effector systems
(BioMed Central, 2010-05)Background: In an effort to better understand the molecular networks that underpin macrophage activation we have been assembling a map of relevant pathways. Manual curation of the published literature was carried out in ... -
Regulation of gene expression during M-G1-phase in fission yeast through Plo1p and forkhead transcription factors
(The Company of Biologists, 2008-04)In fission yeast the expression of several genes during M-G1 phase is controlled by binding of the PCB binding factor (PBF) transcription factor complex to Pombe cell cycle box ( PCB) promoter motifs. Three components of ... -
Direct estimation of the mitochondrial DNA mutation rate in Drosophila melanogaster
(2008-08-01)Mitochondrial DNA (mtDNA) variants are widely used in evolutionary genetics as markers for population history and to estimate divergence times among taxa. Inferences of species history are generally based on phylogenetic ... -
Porcine cysticercosis in southeast Uganda: seroprevalence in Kamuli and Kaliro districts
(2009)The recent recognition of neurocysticercosis as a major cause of epilepsy in Uganda and changes in pig demography have lead to a need to better understand the basic epidemiology of Taenia solium infections in pigs and ... -
Th1 Cells Facilitate the Entry of Th17 Cells to the Central Nervous System during Experimental Autoimmune Encephalomyelitis
(2008)It has recently been proposed that experimental autoimmune encephalomyelitis, once considered the classical Th1 disease, is predominantly Th17 driven. In this study we show that myelin-reactive Th1 preparations devoid of ... -
Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg.
(2009)The potential use of CD4(+)Foxp3(+) Treg as a cellular therapy for autoimmune disease is of great interest. For clinical translation, the key objective is to reverse established disease. Here we demonstrate that myelin ... -
Avian sex chromosomes: dosage compensation matters.
(2009)In 2001 it was established that, contrary to our previous understanding, a mechanism exists that equalises the expression levels of Z chromosome genes found in male (ZZ) and female (ZW) birds (McQueen et al 2001). More ... -
Transmission stage investment of malaria parasites in response to in-host competition
(The Royal Society, 2007)Conspecific competition occurs in a multitude of organisms, particularly in parasites, where several clones are commonly sharing limited resources inside their host. In theory, increased or decreased transmission investment ... -
Disentangling Genetic Variation for Resistance and Tolerance to Infectious Diseases in Animals
(American Association for the Advancement of Science, 2007-11)Hosts can in principle employ two different strategies to defend themselves against parasites: resistance and tolerance. Animals typically exhibit considerable genetic variation for resistance (the ability to limit parasite ... -
Parasite genetic diversity does not influence TNF-mediated effects on
(Cambridge University Press, 2006)The pro-inflammatory cytokine tumour necrosis factor alpha (TNF-α) is associated with malaria virulence (disease severity) in both rodents and humans. We are interested in whether parasite genetic diversity influences ... -
Parasite-intrinsic factors can explain ordered progression of trypanosome antigenic variation
(National Academy of Sciences, 2007)Pathogens often persist during infection because of antigenic variation, in which they evade immunity by switching between distinct surface antigen variants. A central question is how ordered appearance of variants, an ... -
The effect of parental rearing conditions on offspring life history in Anopheles stephensi
(BioMedCentral, 2007)Background The environmental conditions experienced by parents are increasingly recognized to impact the success of offspring. Little is known on the presence of such parental effects in Anopheles. If present, parental ... -
Can fungal biopesticides control malaria?
(Nature Publishing Group, 2007)Recent research has raised the prospect of using insect fungal pathogens for the control of vector-borne diseases such as malaria. In the past, microbial control of insect pests in both medical and agricultural sectors ...
