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dc.contributor.authorKamel, Karimen
dc.date.accessioned2019-02-15T14:31:40Z
dc.date.available2019-02-15T14:31:40Z
dc.date.issued1963
dc.identifier.urihttp://hdl.handle.net/1842/34823
dc.description.abstracten
dc.description.abstractI THE FIBRINOLYTIC SYSTEM: A review of the literature is presented together with an evaluation of the present methods for the measurement of its parameters.en
dc.description.abstractThe methods adopted in the course of this study include (l) the heated fibrin plate for the estimation of plasmin, (2) the plasma euglobulin lysis time for the determination of the overall "fibrinolytic activity" and/or the activator, (3) a caseinolytic method for the measurement of plasminogen and (A) an assay of antifibrinolysins.en
dc.description.abstract(a) A study of the fibrinolytic system in some congenital and hereditary haemorrhagic disorders was carried out in order to evaluate the theory that, in vivo, the coagulation and the fibrinolytic processes normally exist in a state of dynamic equilibrium. It was thought that if this theory held true, then a change in one of the components of the equilibrium state, (for example a delayed or dim¬ inished coagulation mechanism as in certain haemorrhagic disorders) would lead to a balancing diminution in the other component and hence to a decrease in fibrinolytic activity. It was found that the fibrinolytic system was normal in these states and that its activation during and following operative procedures,followed a normal sequence. These findings may cast some doubt on the theory of physiological dynamic haemostasis.en
dc.description.abstract(b) The changes in the fibrinolytic system observed in eighteen patients with cardiac disease undergoing open-heart surgery on cardio-pulmonary bypass with hypothermia were studied. This revealed that excessive fibrinolysis is inevitable at some time during the procedure, but need not, however, cause any serious consequences as shown in the patients studied. Plasminogen and fibrinogen diminution was noted, while changes in the aatifibrinolysins were less clear.en
dc.description.abstractII A COMPARISON OF HAPTOGLOBIN PHENOTYPES IN HAEMOPHILICS AND NORMAL PERSONS IN SCOTLAND: Haptoglobin phenotyping by starch-gel electrophoresis was done in thirty-eight patients with haemophilia and other congenital and hereditary haemorrhagic disorders, and in one hundred normal individuals in Scotland. This study was undertaken in an endeavour to find a genetic link for these conditions and as a way of investigating the relation between blood groups and/or haptoglobin types and disease states.en
dc.description.abstractHaptoglobin type distribution in these conditions matched that in the control series which, in its turn, was in accord with that of neighbouring populations.en
dc.description.abstractIII PLASMA THROMBOPLASTIN GENERATION BLOCKING ANTICOAGULANT IN HAEMOPHILIA. GLINICO-PATHOLOGICAL STUDY OF A REFRACTORY CASE: This investigation presented a clinical study, together with an attempt at the characterization of and speculations on the aetiology of an unusual form of circulating anticoagulant which developed in a patient with classical haemophilia. The anticoagulant in this case blocked the interaction leading to the generation of plasma thromboplastin activity, but did not destroy factor VIII.en
dc.publisherThe University of Edinburghen
dc.relation.ispartofAnnexe Thesis Digitisation Project 2019 Block 22en
dc.relation.isreferencedbyen
dc.titleInvestigations into the fibrinolytic system and haptoglobin types in certain hereditary and acquired haemostatic disorders and the presence of circulating anticoagulants in such statesen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen


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