(i) The combined plasmoquine and quinine
treatment is definitely superior to simple
quinine treatment in the following respects: -
(a) In producing a definite reduction
in the duration of the temperature
in the individual.
(b) In the destruction of gametocytes
especially in the case of M.T.
infection where it has a definite
effect but not to the extent
claimed by the manufacturers.
(ii) No appreciable advantage can be claimed
by this treatment in the reduction of splenic
(iii) Toxic symptoms were manifested in 10.7%
of cases treated and appeared after the administration
of an average dose of 0.12 gram approximately.
The majority of these cases showed these
symptoms after 48 hours of administration.
(iv) Toxic symptoms noted are Gastralgia,
abdominal pain, vomiting, diarrhoea, dysenteric
symptoms, cyanosis and paleness of the skin and
(v) Cyanosis or methaemoglobinaemia was
not noticed in these cases as by other observers,
as all the cases which were treated have dark
skins, and lesser degrees of cyanosis cannot be
detected without spectroscopic blood examinations
which were not carried out.
(vi) The toxic effects of plasmoquine require
careful watching and medical supervision is at
all times indispensable.
Dosage recommended 0.02 gram, twice a day
for twenty -one days seems to be a safe one.
(vii) The provocative effect of plasmoquine
in case of double infection has not been proved.
(viii) Prophylactic use of plasmoquine as a
routine antimalarial measure is not advisable.
(ix) Considering all these points it is not
desirable to recommend this method of treatment as
a universal routine measure, but with proper
safeguard this treatment may be adopted in B.T.
infection and in the cases of crescents.