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The myeloma: its cytology, biochemistry and clinical features

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MacDonaldAM_1941redux.pdf (43.10Mb)
Date
1941
Author
MacDonald, A. M.
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Abstract
 
 
#1. The myeloma is defined, a short history of the disease is given and the possibility of different types discussed. || #2. Reports of 29 cases of myeloma are given and misdiagnosed cases, 2 cases of chloroma and 1 case of plasma cell leukaemia. || #3. The relationship between the malignant cell of myeloma (the myeloma cell) and trie plasma cell is discussed; a short history of the plasma cell and a description is given; the myeloma cell and the plasma cell are compared. || #4. Tne myeloma cell and the plasma cell are con - sidered to be quite different and for this reason the name plasmacytoma is discouraged. || #5. The myeloma cell is probably a malignant haemocytoblast and the name haemocytoblastoma is suggested for the tumour. || #6. The myeloma is mainly a disease of bone marrow, and is confined to bone marrow, but metastases to the viscera may occur and tumours of this type outside the skeletal system are recognised]. || #7. The association between myeloma and leukaemia is discussed with special reference to plasma cell leukaemia. || #8. The biochemical findings in cases of myeloma are described, with particular attention paid to the plasma proteins. The meaning of hyper - proteinaemia in myelomatosis is discussed and the association between this phenomenon and Bence-Jones proteinuria and the blood sedimentation rate is discussed. || #9. The association between serum proteins and amyloid is described. || #10. The importance of X -ray photography in recognising the pathological process is stressed and the necessity of verification by sternal puncture is stressed. || #11. The interpretation of the differential count in bone narrow smears is discussed and a method of puncturing the sternum is described. || #12. Prognosis is poor in the multiple myelomatosis and so- called solitary myeloma, but good in the extra-medullary type. || #13. Treatment is unsatisfactory. X -rays, however, do give the patient a loner lease of life but they are not curative.
 
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http://hdl.handle.net/1842/34987
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