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An attempt to induce calcification and healing in experimental tuberculosis of guinea pigs

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MacDonaldIC_1936redux.pdf (20.49Mb)
Date
1936
Author
MacDonald, Iain Campbell
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Abstract
 
 
(1) With the therapeutic means employed in this experiment no marked prophylactic or curative results were obtained in any group as compared with the controls which received no treatment.
 
(2) Calcium and vitamin D did not appear to be a factor of importance in the production of calcification when given in the dosage and by the method used here. They could not be said to have influenced the amount and rate of spread of the disease nor led to any unusual degree of fibroblastic reaction.
 
(3) As judged by the various criteria used to assess the effect of the treatments it was found that tendencies suggesting a favourable effect were most frequently noted in the calcium, cholesterol and tuberculin group.
 
Calcification occurred with such frequency in this group, that, in conjunction with the other favourable effects noted, the combination may be regarded as of sufficient significance to warrant fuller investigation.
 
No results were obtained which would justify any of the therapeutic measures adopted in this experiment being considered applicable to the treatment of tuberculosis in humans.
 
URI
http://hdl.handle.net/1842/34992
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