Sulphanilamide, sulphapyridine and sulphathiazole are exceedingly potent drugs in the treatment
of gonorrhoea, and there is not much to choose between
them in the matter of cure.
Toxic effects were frequent but were never
severe. They were much more marked with sulphapyridine,
especially in the female, but we seem to
have found the solution to this in sulphathiazole.
All cases need observation and strict instructions
how to take the drug in order to secure the maximum
benefit. It is not enough to give a box of tablets,
promise cure, and neglect tests for cure.
Relapses occurred in the majority of cases after
inadequate doses given by the patients' private
practitioners, and no good results can be obtained
by using the suiphanilamides again in adequate
doses until the patient loses his drug resistance
which takes about fourteen days. Sulphapyridine
should in an uncomplicated case dry up discharge
in twenty-four hours. If it fails to do so, suspect
The Gonococcal Complement Fixation test in the
male is of importance as a test in doubtful clinical cases without a positive smear, and in the female
as a test for cure. Early cases under treatment
with sulphapyridine (M & B 693) however, never