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Observations on immune responses of sheep to Orf virus

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MaedaAD_1980redux.pdf (35.99Mb)
Date
1980
Author
Maeda, Amy Denise
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Abstract
 
 
Sheep infected and re-infected with orf virus responded with lesions which evolved through classical pox stages of papule, vesicle, pustule and scab. In susceptible sheep they resolved within five weeks whereas in re-infected sheep there was an accelerated response, the lesions healing within three weeks.
 
Experiments were designed to correlate the roles of humoral and cell-mediated immune responses with clinical responses. Sera were analysed for changes in the levels of total proteins, serum fractions, IgM, IgGl, IgG2 and antibodies. Leucuocytes from infected and re-infected sheep were also assayed for cell-mediated immune responses.
 
Changes in the total serum proteins of infected and re-infected sheep, pre-challenge and post-challenge were not significant. Contrarily, there were significant in¬ creases in the gammaglobulin levels in re-infected sheep and slight increases in the levels in infected susceptible sheep.
 
IgM levels of infected and re-infected sheep were not markedly altered. IgGl and IgG2, in contrast, increased significantly after infection and re-infection. The in¬ creases correlated positively with orf antibody titres.
 
The rate of antibody production was significantly slower in infected sheep than in re-infected sheep and the titres attained were much lower in susceptible sheep than in re-infected sheep.
 
URI
http://hdl.handle.net/1842/35113
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