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dc.contributor.authorMaeda, Amy Deniseen
dc.date.accessioned2019-02-15T14:34:49Z
dc.date.available2019-02-15T14:34:49Z
dc.date.issued1980
dc.identifier.urihttp://hdl.handle.net/1842/35113
dc.description.abstracten
dc.description.abstractSheep infected and re-infected with orf virus responded with lesions which evolved through classical pox stages of papule, vesicle, pustule and scab. In susceptible sheep they resolved within five weeks whereas in re-infected sheep there was an accelerated response, the lesions healing within three weeks.en
dc.description.abstractExperiments were designed to correlate the roles of humoral and cell-mediated immune responses with clinical responses. Sera were analysed for changes in the levels of total proteins, serum fractions, IgM, IgGl, IgG2 and antibodies. Leucuocytes from infected and re-infected sheep were also assayed for cell-mediated immune responses.en
dc.description.abstractChanges in the total serum proteins of infected and re-infected sheep, pre-challenge and post-challenge were not significant. Contrarily, there were significant in¬ creases in the gammaglobulin levels in re-infected sheep and slight increases in the levels in infected susceptible sheep.en
dc.description.abstractIgM levels of infected and re-infected sheep were not markedly altered. IgGl and IgG2, in contrast, increased significantly after infection and re-infection. The in¬ creases correlated positively with orf antibody titres.en
dc.description.abstractThe rate of antibody production was significantly slower in infected sheep than in re-infected sheep and the titres attained were much lower in susceptible sheep than in re-infected sheep.en
dc.publisherThe University of Edinburghen
dc.relation.ispartofAnnexe Thesis Digitisation Project 2019 Block 22en
dc.relation.isreferencedbyAlready catalogueden
dc.titleObservations on immune responses of sheep to Orf virusen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen


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