Edinburgh Research Archive logo

Edinburgh Research Archive

University of Edinburgh homecrest
View Item 
  •   ERA Home
  • Edinburgh Medical School
  • Edinburgh Medical School thesis and dissertation collection
  • View Item
  •   ERA Home
  • Edinburgh Medical School
  • Edinburgh Medical School thesis and dissertation collection
  • View Item
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

Substances responsible for the buffering power of biological fluids with particular reference to urine

View/Open
MalcolmGD_1935redux.pdf (5.125Mb)
Date
1935
Author
Malcolm, Gordon Douglas
Metadata
Show full item record
Abstract
 
 
CLAUDE BERNARD'S postulation concerning the presence of a constant internal environment in the higher animals serves admirably to explain the nature of this essay. Speaking of this environment he said, "The constancy of the environment presupposes such a perfection of the organism that at every moment external variations are compensated and equilibriated". This essay attempts to describe the nature of those substances responsible for the maintenance of a constant hydrogen ion concentration in the body fluids, or, in other words, the buffers in these fluids. A buffer is a substance capable of producing either H or OH ions, but which is so weakly ionised in solution that changes in its concentration make very little difference to the total amount of whichever ion it produces. Of such a nature are the salts of weak acids and bases, or mixtures of weak acids or bases with their salts, and the proteins. How these effect their buffering action is best demonstrated by an example of one in action. Supposing we add to the buffer NaA the strong acid HC1. The result is: HCl + NaA= NaCl + HA This HA is so weakly dissociated that the pH of the solution shows little change.
 
URI
http://hdl.handle.net/1842/35127
Collections
  • Edinburgh Medical School thesis and dissertation collection

Library & University Collections HomeUniversity of Edinburgh Information Services Home
Privacy & Cookies | Takedown Policy | Accessibility | Contact
Privacy & Cookies
Takedown Policy
Accessibility
Contact
feed RSS Feeds

RSS Feed not available for this page

 

 

All of ERACommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsPublication TypeSponsorSupervisorsThis CollectionBy Issue DateAuthorsTitlesSubjectsPublication TypeSponsorSupervisors
LoginRegister

Library & University Collections HomeUniversity of Edinburgh Information Services Home
Privacy & Cookies | Takedown Policy | Accessibility | Contact
Privacy & Cookies
Takedown Policy
Accessibility
Contact
feed RSS Feeds

RSS Feed not available for this page