The history of our knowledge of anaemia can be divided into three
epochs. The first period extends from 1554, when Johannes Lange first
published an account of chlorosis, till the publication of Addison's
second paper in 1855. During this time the accounts of anaemia are descriptive
in nature. The second, or clinical period, ended in 1913 when
Thipple's researches began to appear in print. The approach to the
problem during the past twenty-five years has been experimental.