The scope of the present paper is defined in its title. It is intended
to recount briefly the earlier views, on the place of diet in the
treatment of Pernicious Anaemia; to indicate the reasons which led to
the supposition,'on theoretical grounds, that a diet rich in liver
might prove a valuable tnerapeutic measure; and finally to describe
the results which ha/ve, in practice, attended the adoption of this
mode of treatment, it is not proposed to discuss the question of aetiology,
which, far from being clarified by this recent tnerapeutic advance,
has been rendered, if possible, even more obscure than before.
1. Treatment of patients suffering from Pernicious Anaemia with liver,
or a suitable extract of liver, appears to bring about, in practically
all cases, a prompt and complete remission.
2. The commonest cause of an unsatisfactory result is the use of an
insufficient quantity of liver. Complications, such as infection
may retard the improvement, as also may previous repeated blood
transfusions. Very rarely, a case may fail to respond to liver for
no obvious reason, even although the diagnosis of Pernicious Anaemia
appears to be correct
3. Neural Symptoms usually improve, but to a less extent than those
referable to other systems.
4. The condition brought about by adequate liver treatment is one of
"remission”, not "cure". Apart from the fact that relapse occurs
if the treatment is discontinued, the patients (though symptomatic-well)
continue to exhibit gastric achylia, and a somewhat abnormal
condition of the blood as shown by measurement.