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Psychological Medicine

dc.contributor.authorTierney, K. M.en
dc.contributor.authorLonie, J. A.en
dc.contributor.authorDonaghey, C.en
dc.contributor.authorEbmeier, K. P.en
dc.contributor.authorLee, A.en
dc.contributor.authorHerrmann, L. L.en
dc.contributor.authorO'Carroll, R. E.en
dc.date.accessioned2010-08-06T10:10:02Z
dc.date.available2010-08-06T10:10:02Z
dc.date.issued2009-01
dc.identifier.issn0033-2917
dc.identifier.urihttp://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=2939024
dc.identifier.urihttp://hdl.handle.net/1842/3532
dc.description.abstractBackground. The dual task paradigm (Baddeley et al. 1986; Della Sala et al. 1995) has been proposed as a sensitive measure of Alzheimer's dementia, early in the disease process. Method. We investigated this claim by administering the modified dual task paradigm (utilising a pencil-and-paper version of a tracking task) to 33 patients with amnestic mild cognitive impairment (aMCI) and 10 with very early Alzheimer's disease, as well as 21 healthy elderly subjects and 17 controls with depressive symptoms. All groups were closely matched for age and pre-morbid intellectual ability. Results. There were no group differences in dual task performance, despite poor performance in episodic memory tests of the aMCI and early Alzheimer's disease groups. In contrast, the Alzheimer patients were specifically impaired in the trail-making test B, another commonly used test of divided attention. Conclusions. The dual task paradigm lacks sensitivity for use in the early differential diagnosis of Alzheimer's disease.en
dc.language.isoen
dc.publisherCambridge University Pressen
dc.subjectAnterograde amnesiaen
dc.subjectdepressive disorderen
dc.subjectdysthymic disorderen
dc.subjectgeriatric assessmenten
dc.subjectmemory disordersen
dc.subjectneuropsychologyen
dc.titleDual task performance in early Alzheimer's disease, amnestic mild cognitive impairment and depressionen
dc.typeArticleen
dc.identifier.doi10.1017/S0033291708003346
rps.issue1en
rps.volume39en
rps.titlePsychological Medicineen
dc.extent.pageNumbers23-31en
dc.date.updated2010-08-06T10:10:02Z
dc.identifier.eIssn1469-8978


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