The concentration -variations of chlorides,
acid and pepsin, in gastric contents, have been
One hundred investigations of chlorides
and acid alone, and fifteen of pepsin were carried
out in both normal and pathological cases. Estimations
of these constituents were also performed on
the secretion obtained from an isolated pouch, with
nervous connections intact, constructed in the lower
half of the fundus of a dog's stomach.
I. The chief diagnostic value of estimations of
the chlorides, in addition to that of the
acid, lies in assisting differentation
of such pathological conditions of the
stomach as are characterised by complete
absence of 'free' hydrochloric acid,
II. The determination of pepsin -variations seems .
to be of most service in distinguishing
between Carcinoma of the Stomach and
Gastric or Duodenal Ulcer.
III. The mechanism of control of gastric acidity
is dependent upon several contributory
The suggestion is made that the gland -cells
of the pyloric segment of the stomach
represent the principal source of secreted