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dc.contributor.authorMitchell, Thomas Carlyleen
dc.date.accessioned2019-02-15T14:37:27Z
dc.date.available2019-02-15T14:37:27Z
dc.date.issued1929
dc.identifier.urihttp://hdl.handle.net/1842/35365
dc.description.abstracten
dc.description.abstractThe concentration -variations of chlorides, acid and pepsin, in gastric contents, have been studied. One hundred investigations of chlorides and acid alone, and fifteen of pepsin were carried out in both normal and pathological cases. Estimations of these constituents were also performed on the secretion obtained from an isolated pouch, with nervous connections intact, constructed in the lower half of the fundus of a dog's stomach. I. The chief diagnostic value of estimations of the chlorides, in addition to that of the acid, lies in assisting differentation of such pathological conditions of the stomach as are characterised by complete absence of 'free' hydrochloric acid, II. The determination of pepsin -variations seems . to be of most service in distinguishing between Carcinoma of the Stomach and Gastric or Duodenal Ulcer. III. The mechanism of control of gastric acidity is dependent upon several contributory factors. The suggestion is made that the gland -cells of the pyloric segment of the stomach represent the principal source of secreted neutral chiorids.en
dc.publisherThe University of Edinburghen
dc.relation.ispartofAnnexe Thesis Digitisation Project 2019 Block 22en
dc.relation.isreferencedbyen
dc.titleSignificance of variation in concentration of chlorides, acid, and pepsin, in the gastric contents, with particular reference to the control of gastric acidityen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnameMD Doctor of Medicineen


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