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dc.contributor.advisorThomas, Stephen
dc.contributor.advisorLusby, Paul
dc.contributor.authorCarney, Jonathan Robert
dc.date.accessioned2019-07-05T10:41:48Z
dc.date.available2019-07-05T10:41:48Z
dc.date.issued2019-07-01
dc.identifier.urihttp://hdl.handle.net/1842/35699
dc.description.abstractThe development of new first-row transition metal catalysts as both replacements for precious metals catalysts and in the search for novel reactivity is a crucial evolution for catalysis. Manganese is a non-toxic, inexpensive and Earth-abundant metal, making it a perfect candidate for catalysis. Despite this, manganese catalysis has not undergone the same development as for other Earth-abundant metals. The manganese-catalysed hydrosilylation and hydroboration of alkenes has been developed to give hydrofunctionalisation products in typically good yields (up to >95%) with control of regio- and chemo-selectivity. This work uses a bench-stable precatalyst/ activator manifold allowing for a simple methodology, ideal for the nonspecialist. This represents the first example of a developed methodology for the manganesecatalysed hydrosilylation of alkenes. This methodology uses a bis(imino)pyridine manganese(II) pre-catalyst which has previously been unreactive in related reactions. The critical discovery has been in the use of an alkoxide activation system which enables the generation of a catalytically-active manganese species.en
dc.language.isoenen
dc.publisherThe University of Edinburghen
dc.relation.hasversionRecent Advances of Manganese Catalysis for Organic Synthesis Carney, J. R.; Dillon, B. R.; Thomas, S.P. Eur. J. Org. Chem. 2016, 3912-3929en
dc.relation.hasversionBorane-Catalysed Hydroboration of Alkynes and Alkenes N. W. J. Ang, C. S. Buettner, S. Docherty, A. Bismuto, J. R. Carney and J. H. Docherty, Synthesis, 2018, 50, 803–808en
dc.relation.hasversionManganese-Catalyzed Hydrofunctionalization of Alkenes Carney, J. R.; Dillon, B. R.; Campbell, L.; Thomas, S.P. Angew. Chem. Int. Ed. 2018, 57, 10620-10624en
dc.subjectmanganeseen
dc.subjectcatalysisen
dc.subjecthydrosilylationen
dc.subjecthydroborationen
dc.titleManganese-catalysed hydrofunctionalisation of alkenesen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen


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