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dc.contributor.advisorStone, Jonen
dc.contributor.advisorCarson, Alanen
dc.contributor.authorHoeritzauer, Anne Ingriden
dc.date.accessioned2020-04-30T12:30:15Z
dc.date.available2020-04-30T12:30:15Z
dc.date.issued2020-06-27
dc.identifier.urihttps://hdl.handle.net/1842/37019
dc.identifier.urihttp://dx.doi.org/10.7488/era/320
dc.description.abstractUro-neurological disorders are those in which there is a disturbance of bladder function related to a neurological cause. However, many patients with a combination of urological and neurological symptoms, such as bladder voiding dysfunction and leg weakness or numbness, are not found to have explanatory abnormalities despite adequate clinical and radiological investigation, so-called ‘scan negative’ patients. In this PhD patients with ‘scan negative’ uro-neurological diagnoses were primarily investigated through studies of patients presenting with suspected Cauda Equina Syndrome and to a lesser extent Chronic Urinary Retention (including Fowler’s syndrome). The PhD goal was to deeply phenotype patients with ‘scan negative’ Uro- neurological disorders and in so doing, to improve our scientific understanding of these presentations and inform the development of clinical trials. The PhD explores the historical literature linking patients with idiopathic urological dysfunction and functional disorders, reviews the incidence, research and definitions of cauda equina syndrome and phenotypes patients in a retrospective and prospective manner who present with acute scan negative urological dysfunction (‘scan negative’ cauda equina syndrome) as well as investigates for evidence of functional disorders in chronic scan negative urological dysfunction (Fowler’s syndrome) and evidence of urological dysfunction in patients with functional disorders and neurological dysfunction.en
dc.language.isoen
dc.publisherThe University of Edinburghen
dc.relation.hasversionHoeritzauer I, Phe V, Panicker JN. Urological symptoms and functional neurologic disorders. Hand Clin Neurol; 2016; 139:469-481en
dc.relation.hasversionHoeritzauer I, MRCP, Wood M, Copley P MRCS, Demetriades AK FRCSEd and Woodfield J. What is the Incidence of Cauda Equina Syndrome? In press Journal of Neurosurgery: Spine.en
dc.relation.hasversionHoeritzauer I, CM Doherty, S Thompson, R Kee, A Carson, N Eames, J Stone. ‘Scan Negative’ Cauda Equina Syndrome: evidence of functional disorder from a prospective case series. Brit J of Neurosurg. 2015; 29 (2):178-180en
dc.relation.hasversionIngrid Hoeritzauer, Savva Pronin, Alan Carson, Patrick Statham, Andreas K. Demetriades, Jon Stone. The clinical features and outcome of scan negative and scan positive cases in suspected cauda equina syndrome - a retrospective study of 276 patients. J Neurol. 2018 Dec;265(12):2916-2926en
dc.relation.hasversionHoeritzauer I, Jon Stone, Clare Fowler, Suzy Elneil, Alan Carson, Jalesh Panicker. Fowler’s syndrome of Urinary Retention: a Retrospective Study of Comorbidity. Neurourology and Urodynamics. 2016; 35(5): 601-603.en
dc.relation.hasversionHoeritzauer I, Phe V, Panicker JN. Urological symptoms and functional neurologic disorders. Hand Clin Neurol; 2016; 139:469-481en
dc.subjectCauda Equina Syndromeen
dc.subjectscan negative patientsen
dc.subjectscan negativeen
dc.subjectFunctional Neurological Disorderen
dc.subjectbladder brain networken
dc.subjectbladder dysfunctionen
dc.subjectFowler’s syndromeen
dc.subjecturinary retentionen
dc.titleClinical features and prognosis of ‘scan negative’ uro-neurological disordersen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen


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