dc.contributor.advisor | Nudelman, Fabio | |
dc.contributor.advisor | McKeown, Neil | |
dc.contributor.author | Machado de los Toyos, Laura María | |
dc.date.accessioned | 2022-12-07T14:36:41Z | |
dc.date.available | 2022-12-07T14:36:41Z | |
dc.date.issued | 2022-12-07 | |
dc.identifier.uri | https://hdl.handle.net/1842/39572 | |
dc.identifier.uri | https://github.com/laura-machadodelostoyos/Thesis | en |
dc.identifier.uri | http://dx.doi.org/10.7488/era/2822 | |
dc.description.abstract | Developing a new drug storage system is imperative, especially for macromolecules with limited shelf-lives, pharmaceutical cures for unforeseeable epidemics, and drugs with short-lived therapeutic windows.
In this work, calcite is proposed as a new system for drug storage. Since it is a single crystal, it is impenetrable by the primary agents of decay (oxygen, humidity and UV radiation).
The system explored in this work achieved 20% occlusion in mass, which is 5% higher than the most excellent occlusion reported in the literature. This is the first evidence of a neutral capsule occluded inside of calcite, which breaks with the assumption that charge is a requisite for crystal-additive interactions.
Using CLSM and FIB-SEM tomography, three-dimensional models are built of the occluded
capsules in crystals. The occlusion patterns observed revolve around the third-order axis of symmetry. Size selectivity of around 1 µm has been calculated, although most of the occluded capsules observed are in the 100-300 nm range.
We propose that this system be applied at the manufacturer scale and that the drugs stored in the crystals can later be processed into consumer-ready pharmaceuticals when needed.
The pharmaceutical industry can apply this technology to control the spread of infectious diseases or simply profit from price fluctuations on synthetic precursors. | en |
dc.language.iso | en | en |
dc.publisher | The University of Edinburgh | en |
dc.subject | calcite | en |
dc.subject | composites | en |
dc.subject | occlusion in crystals | en |
dc.subject | drug delivery | en |
dc.title | Occlusion of polymeric capsules in calcite single crystals for storage of active pharmaceutical ingredients | en |
dc.type | Thesis or Dissertation | en |
dc.type.qualificationlevel | Doctoral | en |
dc.type.qualificationname | PhD Doctor of Philosophy | en |