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dc.contributor.advisorNudelman, Fabio
dc.contributor.advisorMcKeown, Neil
dc.contributor.authorMachado de los Toyos, Laura María
dc.date.accessioned2022-12-07T14:36:41Z
dc.date.available2022-12-07T14:36:41Z
dc.date.issued2022-12-07
dc.identifier.urihttps://hdl.handle.net/1842/39572
dc.identifier.urihttps://github.com/laura-machadodelostoyos/Thesisen
dc.identifier.urihttp://dx.doi.org/10.7488/era/2822
dc.description.abstractDeveloping a new drug storage system is imperative, especially for macromolecules with limited shelf-lives, pharmaceutical cures for unforeseeable epidemics, and drugs with short-lived therapeutic windows. In this work, calcite is proposed as a new system for drug storage. Since it is a single crystal, it is impenetrable by the primary agents of decay (oxygen, humidity and UV radiation). The system explored in this work achieved 20% occlusion in mass, which is 5% higher than the most excellent occlusion reported in the literature. This is the first evidence of a neutral capsule occluded inside of calcite, which breaks with the assumption that charge is a requisite for crystal-additive interactions. Using CLSM and FIB-SEM tomography, three-dimensional models are built of the occluded capsules in crystals. The occlusion patterns observed revolve around the third-order axis of symmetry. Size selectivity of around 1 µm has been calculated, although most of the occluded capsules observed are in the 100-300 nm range. We propose that this system be applied at the manufacturer scale and that the drugs stored in the crystals can later be processed into consumer-ready pharmaceuticals when needed. The pharmaceutical industry can apply this technology to control the spread of infectious diseases or simply profit from price fluctuations on synthetic precursors.en
dc.language.isoenen
dc.publisherThe University of Edinburghen
dc.subjectcalciteen
dc.subjectcompositesen
dc.subjectocclusion in crystalsen
dc.subjectdrug deliveryen
dc.titleOcclusion of polymeric capsules in calcite single crystals for storage of active pharmaceutical ingredientsen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen


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