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dc.contributor.advisorColegrave, Nick
dc.contributor.advisorWest, Stuart
dc.contributor.authorHall, Alex R.
dc.date.accessioned2010-10-15T14:20:18Z
dc.date.available2010-10-15T14:20:18Z
dc.date.issued2009
dc.identifier.urihttp://hdl.handle.net/1842/3977
dc.description.abstractExperiments with microbes are a powerful tool for addressing general questions in evolutionary ecology. Microbial evolution is also interesting in its own right, and often clinically relevant. I have used experimental evolution of bacteria (Pseudomonas spp.) in controlled laboratory environments to investigate the role of environmental heterogeneity in the evolution of phenotypic diversity. Some of my results provide insight on general processes, while others are specific to bacteria. (1) I have shown that variation in resource supply affects the evolution of niche breadth in complex environments containing a range of available resources, leading to a peak in phenotypic diversity at intermediate levels. (2) I have found that resource availability also affects selection against redundant phenotypic characters, which is strongest when resources are scarce. (3) Using experiments with bacteria and their protozoan predators, I have found that selection for predator resistance varies with resource supply during a model adaptive radiation. (4) I have looked at the role of periodic bottlenecks in population size in the evolution of antibiotic-resistant bacteria. My results highlight the importance of biochemical constraints specific to different resistance mutations. (5) Finally, I have shown that bacterial adaptation to novel carbon substrates affects different growth parameters simultaneously, and that the same response is seen in environments that maintain different levels of phenotypic diversity. These findings emphasize the role of environmental heterogeneity in the evolution of phenotypic diversity, but also show how ecological and genetic factors can constrain adaptation to a given niche within a heterogeneous environment.en
dc.contributor.sponsorBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.language.isoenen
dc.publisherThe University of Edinburghen
dc.relation.hasversionHall, A.R. & Colegrave, N. 2007. How does resource supply affect evolutionary diversification? Proc. R. Soc. B 274, 73-78.en
dc.relation.hasversionHall, A.R. & Colegrave, N. 2008. Decay of unused characters by selection and drift. Journal of Evolutionary Biology 21, 610-617.en
dc.relation.hasversionHall, A.R., Meyer, J.R. & Kassen, R. 2008. Selection for predator resistance varies with resource supply in a model adaptive radiation. Evolutionary Ecology Research 10, 735-746.en
dc.subjectevolutionary ecologyen
dc.subjectMicrobial evolutionen
dc.subjectphenotypic diversityen
dc.subjectenvironmental heterogeneityen
dc.titleExperimental evolution with bacteria in complex environmentsen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen


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