Roslin Institute thesis and dissertation collection
The Roslin Institute is a BBSRC Institute incorporated with the Royal (Dick) School of Veterinary Studies. The Institute undertakes research within the framework of BBSRC Institute Strategic Programmes focussed on the health and welfare of animals, and applications of basic animal sciences in human and veterinary medicine, the livestock industry and food security.
This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.
Recent Submissions
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Genetics of health and fertility in dairy cattle
(The University of Edinburgh, 1997) -
Effects of nutrient modification on two bone disorders on poultry
(The University of Edinburgh, 1995) -
Role of follicular fluid proteins in the control of gonadotrophin secretion and follicular development in the heifer
(The University of Edinburgh, 1991) -
Role of growth hormone, insulin-like growth factor-I and insulin in the control of ovarian follicular growth and development in the heifer
(The University of Edinburgh, 1992) -
Defining mechanisms of neurodegeneration associated with protein misfolding diseases
(The University of Edinburgh, 2015-11-27)Protein misfolding diseases (PMDs) are a broad group of disorders including Alzheimer’s, Parkinson’s and prion diseases. They are characterised by the presence of aggregated, misfolded host proteins which are thought to ... -
Detecting ancestral junctions in inbred populations
(The University of Edinburgh, 2005) -
Genetics of bovine vaccination
(The University of Edinburgh, 2011-06-27)Infectious disease is an important issue for animal breeders, farmers and governments. Solutions to control infectious disease are needed and research focused on the genetic loci determining variation in immune-related ... -
Functional analysis of the non-coding RNAs of murine gammaherpesvirus 68
(The University of Edinburgh, 2010)Murine gammaherpesvirus 68 (MHV-68) is used as a model for the study of gammaherpesvirus infection and pathogenesis. In the left region of the genome MHV-68 encodes four unique genes, eight viral tRNA-like molecules ... -
Animal sentinel surveillance: evaluating domestic dogs as sentinels for zoonotic pathogen surveillance
(The University of Edinburgh, 2010)The capacity of zoonotic pathogens to infect multiple hosts creates surveillance challenges but also provides opportunities to gather data from animal species that can be used to understand risks to human health. This ... -
Assessment of genetic markers for the improvement of beef quality and consistency
(The University of Edinburgh, 2010)The overall aim of this thesis was to investigate the genetic control of beef quality in a commercial population of Aberdeen Angus-sired cattle with a view to trait improvement. The population studied included 500 ... -
Detection and characterisation of quantitative trait loci affecting muscle and growth phenotypes in sheep
(The University of Edinburgh, 2010)This thesis addresses the dissection and characterisation of quantitative trait loci (QTL) affecting production traits in sheep. Firstly, the association between specific genetic polymorphisms and complex variation in ... -
Role of domestic dogs in diseases of significance to humans and wildlife health in central Chile
(The University of Edinburgh, 2010)The higher proximity among humans, domestic animals and wildlife favours disease spill-over both from wildlife to domestic animals and vice versa, which is a potential risk for the extinction of wildlife populations and ... -
Pathogenic potential of escherichia coli O26 and sorbitol-fermenting escherichia coli O157:NM
(The University of Edinburgh, 2010)Verocytotoxin-producing Escherichia coli (VTEC) are important human pathogens that may cause diarrhoea, haemorrhagic colitis and haemolytic uremic syndrome (HUS). Worldwide, non-sorbitol-fermenting (NSF) VTEC O157:H7 is ... -
Mechanisms of neurodegeneration and neuronal cell loss in the hippocampus in murine scrapie
(The University of Edinburgh, 2010)Transmissible spongiform encephalopathies (TSEs) or prion diseases are defined by infectivity and by the pathological damage they produce in the central nervous system (CNS), typically involving spongiform degeneration or ... -
Environmental factors affecting interferon-τ expression and secretion by in vitro produced bovine blastocysts
(The University of Edinburgh, 2010)Interferon (IFN)τ is the luteotrophic signal in ruminants and is secreted by bovine blastocysts both in vivo and in vitro. IFNτ secretion is highly variable and its control is only partly understood. Most studies on the ... -
Influence of the immune system on peripherally acquired transmissible spongiform encephalopathy infection with special reference to the role of the follicular dendritic cell
(The University of Edinburgh, 2009)The Transmissible Spongiform Encephalopathies (TSEs) or “prion” diseases are a group of fatal neurodegenerative diseases the aetiology of which is not fully understood. These diseases are characterised by a number of ... -
Role of fibroblast growth factor signalling on the regulation of embryonic stem cells
(The University of Edinburgh, 2008)Fibroblast growth factor (FGF) signalling plays many fundamentally important roles during the development of the mammalian embryo. However, its effects on pluripotent stem cells derived from mouse and human embryos appear ... -
Interactions of foot-and-mouth disease virus with cells in organised lymphoid tissue influence innate and adaptive immune responses
(The University of Edinburgh, 2009)Foot-and-mouth disease virus (FMDV) is one of the most contagious viruses of animals and is recognised as the most important constraint to international trade in animals and animal products. Two fundamental problems remain ...
