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dc.contributor.advisorMcDicken, W. Norman
dc.contributor.advisorBrash, Harry
dc.contributor.advisorPlevris, John N.
dc.contributor.authorInglis, Scott
dc.date.accessioned2010-11-15T16:20:18Z
dc.date.available2010-11-15T16:20:18Z
dc.date.issued2009
dc.identifier.urihttp://hdl.handle.net/1842/4287
dc.description.abstractOesophageal cancer is an aggressive malignancy with an overall five-year survival of 5-10% and two-thirds of patients have irresectable disease at diagnosis. Accurate staging of oesophageal cancer is important as survival closely correlates with the stage of the tumour, nodal involvement and presence of metastases (TNM staging). Endoscopic ultrasonography (EUS) is currently the most reliable modality for providing accurate T and N staging. Depending on findings of the staging, various treatment options including endoscopic, oncological, and surgical treatments may be performed. It was theorised that the development of three-dimensional radial endoscopic ultrasonography would reduce the operator dependence of EUS and provide accurate dimensional and volume measurements to aid planning and monitoring of treatment. This thesis investigates the development of a three dimensional endoscopic ultrasound technique that can be used with the radial echoendoscopes. Various agar-based tissue mimicking material (TMM) recipes were characterised using a scanning acoustic macroscope to obtain the acoustic properties of attenuation, backscatter and speed of sound. Using these results, a number of endoscopic ultrasound phantoms were developed for the in-vitro investigation and evaluation of 3D-EUS techniques. To increase my understanding of EUS equipment, the imaging and acoustic properties of the EUS endoscopes were characterised using a pipe phantom and a hydrophone. The dual ‘single element’ mechanical and ‘multi-element’ electronic echoendoscopes were investigated. Measured imaging properties included dead space, low contrast penetration, and pipe length. The measured acoustic properties included transmitted beam plots, active working frequency and peak pressures. Three-dimensional ultrasound techniques were developed for specific application to EUS. This included the study of positional monitoring systems, reconstruction algorithms and measurement techniques. A 3D-EUS system was developed using a Microscribe positional arm and frame grabber card, to acquire the 3D dataset. A Matlab 3D-EUS toolbox was written to reconstruct and analyse the volumes. The 3D-EUS systems were evaluated on the EUS phantom and in clinical cases. The usefulness of the 3D-EUS systems was evaluated in a cohort of patients, who were routinely investigated by conventional EUS for a variety of upper gastrointestinal pathology. 3D-EUS accurately staged early tumours and provided the necessary anatomical information to facilitate treatment. With regards to more advanced tumours, 3D-EUS was more accurate than EUS in T and N staging. 3D-EUS gave useful anatomical details in a variety of benign conditions such as varicies and GISTs.en
dc.language.isoenen
dc.publisherThe University of Edinburghen
dc.relation.hasversionAn anthropomorphic tissue-mimicking phantom of the oesophagus for endoscopic ultrasound Inglis S., Ramnarine K. V., Plevris J. N., and McDicken W. N.; Ultrasound in Medicine & Biology, Volume 32, Issue 2, February 2006, Pages 249-259en
dc.relation.hasversionA Comparison of the Measurement and Diagnostic Capabilities of 2D and 3D Endoscopic Ultrasound. Inglis S.; Watson R.J.; Ramnarine K.V.; Christie D.; Plevris J.N.; McDicken W.N. European J Ultrasound, Volume 15, Supplement 1, Pages 1-60, 2002en
dc.subjectthree-dimensionalen
dc.subject3Den
dc.subjectendoscopic ultrasounden
dc.subjectEUSen
dc.subjectradialen
dc.subjectphantomen
dc.subjecthydrophoneen
dc.subjectupper GIen
dc.subjectoesophagusen
dc.subjectcancer stagingen
dc.subjectendosonographyen
dc.subjectdiagnostic imagingen
dc.titleDevelopment of a freehand three-dimensional radial endoscopic ultrasonography systemen
dc.typeThesis or Dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD Doctor of Philosophyen


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