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dc.contributor.authorLoewe, Laurenceen
dc.contributor.authorTextor, Volkeren
dc.contributor.authorScherer, Siegfrieden
dc.coverage.spatial3en
dc.date.accessioned2004-03-29T15:29:26Z
dc.date.available2004-03-29T15:29:26Z
dc.date.issued2003
dc.identifier.citationScience, Vol 302, Issue 5650, 1558-1560 , 28 November 2003
dc.identifier.urihttp://www.sciencemag.org/cgi/content/full/302/5650/1558
dc.identifier.uriDOI: 10.1126/science.1087911
dc.identifier.urihttp://hdl.handle.net/1842/445
dc.description.abstractIn natural habitats, bacteria spend most of their time in some form of growth arrest. Little is known about deleterious mutations in such stages, and consequently there is limited understanding of what evolutionary events occur. In a deleterious mutation accumulation experiment in prolonged stationary phase of Escherichia coli, about 0.03 slightly deleterious mutations were observed per genome per day. This is over an order of magnitude higher than extrapolations from fast-growing cells, but in line with inferences from observations in adaptive stationary phase mutation experiments. These findings may affect understanding of bacterial evolution and the emergence of bacterial pathogenicity.en
dc.format.extent795314 bytesen
dc.format.extent420647 bytesen
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/pdfen
dc.language.isoen
dc.publisherAmerican Association for the Advancement of Scienceen
dc.titleHigh Deleterious Genomic Mutation Rate in Stationary Phase of Escherichia colien
dc.typeArticleen


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